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Mechanism of action

Ftalazol is an antimicrobial agent from the group of sulfonamides. It has a wide spectrum of action, including pathogens of intestinal infections. Acts predominantly in the intestinal lumen. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, violates the formation of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.

Indications and usage

Dysentery, colitis, gastroenteritis, bowel surgery (to prevent purulent complications).


Increased individual sensitivity to sulfa drugs, diseases of the blood system, diffuse toxic goiter, kidney disease, acute hepatitis, intestinal obstruction

Dosage and administration

Inside, in acute dysentery, adults in 1-2 days - 1 g 6 times a day, in 3-4 days - 1 g 4 times a day, in 5-6 days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, the second course of treatment is carried out: 1-2 days - 1 g 5 times a day (in the afternoon - every 4 hours, at night - in 8 hours), 3-4 days - 1 g 4 times a day (do not give at night), 5 day - 1 g 3 times a day. The total dose in the second cycle - 21 g, with a light course - 18 g.
Higher doses for adults: single - 2 g, daily - 7 g.
Children up to 3 years old - at 0.2 g / kg in 3 doses for 7 days, older than 3 years - at 0.4-0.75 g 4 times a day.
For other infections, adults in the first 2-3 days are prescribed 1-2 g every 4-6 hours, in the next 2-3 days - half the dose; children - 0.1 g / kg / day in equal doses after 4 hours with a night break, on the following days - 0.2-0.5 g every 6-8 hours.

Adverse reactions

Allergic reactions (rash, fever), vitamin B deficiency (due to inhibition of intestinal microflora), agranulocytosis, aplastic anemia.

Storage conditions

In a dry, dark place at temperatures up to 25 ° C.


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