DIVAZA RESORPTION PILLS

Dosage Form

lozenges.

Composition (per 1 tablet)

Active substances:

Antibodies to the brain-specific protein S-100 affinity purified - 0.006 g *

Antibodies to endothelial NO synthase affinity purified - 0.006 g *

Excipients: lactose monohydrate, microcrystalline cellulose, Magnesium stearate.

* applied to lactose in the form of a mixture of three active aqueous-alcoholic dilutions of the substance, diluted in 100, respectively12, 10030, 100200 time.

Pharmacotherapeutic group

Antihypoxant agent, antioxidant agent, nootropic agent, angioprotective agent.

Pharmacological properties

Pharmacodynamics

Combined drug:

Antibodies to the brain-specific protein S-100 have antioxidant, antihypoxant, neuroprotective, anxiolytic effects. Modify the functional activity of the protein S-100, carrying out the conjugation of information and metabolic processes in the brain. They have a membranotropic action, causing a decrease in amplitude and suppression of the generation of an action potential; modulate synaptic plasticity in the limbic structures of the brain, hippocampus, and reticular formation; contribute to enhancing the inhibitory effects of GABA in the central nervous system. Show the properties of a sigma 1 receptor agonist in vitro.

Inhibit lipid peroxidation.They have a normalizing effect on the integrative activity of the brain, which is manifested by a wide range of balanced psychopharmacological effects: antidepressant, anxiolytic, neuroprotective, antiasthenic, antiamnesic.

Antibodies to endothelial NO synthase increase the activity of the enzyme endothelial NO synthase, restore endothelium production of nitric oxide (NO), eliminate endothelial dysfunction, have an endothelium protective effect, affect NO-dependent vasodilation. Experimentally shown stimulating effect of Divaza on reparative processes in the focus of ischemic brain damage.

The combined use of the components of the drug is accompanied by increased neuroprotective activity of antibodies to S-100 protein, increased vegetative stabilization effect, normalization of vegetative status, synergistic effects of both components on neuronal plasticity, and, consequently, increased resistance of the brain to toxic effects; improves the integrative activity and restores the inter-hemispheric connections of the brain, helps eliminate cognitive impairments, stimulates reparative processes and accelerates the restoration of central nervous system functions, improves mental performance, restores learning and memory processes, normalizes somatovegetative manifestations, increases cerebral blood flow.

Divaza, as well as its components, does not have a sedative and muscle relaxant effect, does not cause addiction and addiction.

Pharmacokinetics

The sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to evaluate the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it impossible to study the pharmacokinetics of the drug Divaz.

Indications

Restoration of the integrative activity of the brain in a wide range of organic lesions of the central nervous system, including those caused by neurodegenerative, cerebrovascular diseases, neuroinfections, and brain injury - as part of complex therapy.

In the complex treatment of ischemic brain lesions in the acute and long-term period.

Monotherapy of somatoform dysfunction of the autonomic nervous system.

Contraindications

Increased individual sensitivity to the components of the drug. Divaza is not recommended for use in children under the age of 18 years due to insufficient data on efficacy and safety for this age.

Pregnancy and lactation period

The safety of using Divaza during pregnancy and lactation has not been studied. If necessary, the appointment of the drug should take into account the risk / benefit ratio.

Dosage and administration

Inside At one time - 1 pill (keep in the mouth until completely dissolved). Apply 1-2 pills 3 times a day outside the meal.Depending on the severity of the condition, in the acute period, the frequency of administration can be increased up to 4-6 times per day.

In case of pronounced organic lesions of the central nervous system, the duration of a course of therapy may reach 4-6 months.

Adverse Effects

Possible reactions increased individual sensitivity to the components of the drug.

Overdosage

In case of accidental overdose, dyspeptic symptoms are possible due to the fillers in the preparation.

Interaction with other drugs

Cases of incompatibility with other drugs have not yet been registered.

Special notes

The preparation contains lactose, and therefore it is not recommended to prescribe it to patients with congenital galactosemia, glucose or malabsorption malabsorption syndrome, or with congenital lactase deficiency.

Divaza does not affect the ability to drive vehicles and other potentially dangerous machinery.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.