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Film Coated Tablets


1 pill contains valaciclovir hydrochloride (in terms of valacyclovir) 500 mg;
Excipients: microcrystalline cellulose, povidone (K 90), kollidon (crosspovidone CL), Calcium stearate;
shell composition: Advantia Prime 190100VA01: Hypromellose (hydroxypropylmethylcellulose), polyethylene glycol (polyethylene oxide, macrogol), titanium dioxide


10 pieces.

Mechanism of action

Valaciclovir is a nucleoside inhibitor of the DNA polymerase of herpes viruses. Blocks viral DNA synthesis and virus replication. In the human body turns into Acyclovir and L-valine; As a result of phosphorylation from acyclovir, active acyclovir triphosphate is formed, which competitively inhibits viral DNA polymerase. The first stage of phosphorylation occurs under the influence of a virus-specific enzyme (for Herpes simplex type 1 and 2, Varicella zoster - viral thymidine kinase, which is found only in cells infected with the virus). More active against Herpes simplex than Varicella zoster.

Indications and usage

In adults: herpes zoster, diseases of the skin and mucous membranes caused by the Herpes simplex virus (including genital herpes), prevention of the recurrence of diseases caused by the Herpes simplex virus.
In adults and children from 12 years of age: prevention of cytomegalovirus infection during organ transplantation.


Hypersensitivity, HIV infection with a CD4 + lymphocyte content of less than 100 / μl, children's age (up to 12 years old with CMV, up to 18 years old - for other indications).

Dosage and administration

Inside (regardless of the meal).

  • When herpes zoster - 1000 mg (2 tab. 500 mg) 3 times a day for 7 days. It is recommended to begin therapy as early as possible (the greatest efficiency is noted if treatment was started within 48 hours from the first appearance of rash).
  • With herpes simplex, incl. relapses, including recurrent genital herpes - 500 mg 2 times a day for 5 days. In case of relapses, the therapy should be started in the prodromal period or immediately after the first signs of the disease appear. In the first episode with a severe course, the duration of therapy can be increased to 10 days.


Elderly patients, people with dehydration during the period of treatment should increase the volume of fluid consumed (the risk of developing acute renal failure). In the treatment of genital herpes, sexual contact should be avoided, because The drug does not protect against transmission. Taking the drug in high doses for a long time in conditions accompanied by severe immunodeficiency (bone marrow transplantation, clinically expressed forms of HIV infection, kidney transplantation) led to the development of thrombocytopenic purpura and hemolytic uremic syndrome, up to a fatal outcome. In the event of side effects from the central nervous system (including agitation, hallucinations, confusion, delusions, seizures and encephalopathy), the drug is canceled.

Drug Interactions

Cimetidine and tubular secretion blockers reduce the effect (reduce the rate, but not the full conversion into acyclovir). In persons with normal QC, dosing regimen correction is not required. Nephrotoxic drugs (including cyclosporin, tacrolimus) increase the risk of nephrotoxicity.

Storage conditions

Store at a temperature not exceeding 30 ° C.

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