Norfloxacin-OBL tablets

Instructions for use Active ingredients Norfloxacin Release form Tablets Composition 1 tablet contains: Norfloxacin 400 mg Pharmacological effect Antimicrobial synthetic agent of the group of fluoroquinolones with a broad spectrum of action. Has a bactericidal effect. By suppressing DNA gyrase, it disrupts the process of DNA supercoiling. Highly active against most gram-negative bacteria: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (including Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis. Active against some gram-positive bacteria (including Staphylococcus aureus). Anaerobic bacteria are resistant to norfloxacin, Enterococcus spp. Are insensitive. and Acinetobacter spp. Resistant to the action of β-lactamases. Pharmacokinetics When taken orally, about 30-40% is absorbed, food intake reduces the rate of absorption. Plasma protein binding is 14%. Norfloxacin is well distributed in the tissues of the urogenital system. Penetrates the placental barrier. About 30% is excreted in the urine unchanged. Indications Infections caused by microorganisms sensitive to norfloxacin: urinary tract infections (except for acute and chronic complicated pyelonephritis), prostatitis, uncomplicated gonorrhea. Contraindications Hypersensitivity. Tendinitis, tendon rupture caused by fluoroquinolones (including in history). Precautions

From the digestive system: nausea, heartburn, anorexia, diarrhea, abdominal pain. From the side of the central nervous system: headache, dizziness, fatigue, sleep disorders, irritability, anxiety. Co side of the urinary system: interstitial nephritis. Application during pregnancy and lactation Norfloxacin is contraindicated during pregnancy and lactation (breastfeeding), since it has been established in experimental studies that it causes arthropathy. Method of administration and dosage For urinary tract infections - 400 mg 2 times a day for 7-10 days; with uncomplicated cystitis - 3-7 days; with chronic recurrent urinary tract infection - up to 12 weeks. In acute bacterial gastroenteritis - 5 days. In acute gonococcal urethritis, pharyngitis, proctitis, cervicitis - 800 mg once. With typhoid fever - 400 mg 3 times a day for 14 days. For the prevention of sepsis - 400 mg 2 times a day. For the prevention of bacterial gastroenteritis - 400 mg / day. For the prevention of travelers' diarrhea - 400 mg / day 1 day before departure and throughout the entire journey (no more than 21 days). For the prevention of recurrence of urinary tract infections - 200 mg / day. In patients with impaired renal function with CC more than 20 ml / min, correction of the dosage regimen is not required. When CC is below 20 ml / min (or serum creatinine concentration is more than 5 mg / 100 ml) and patients on hemodialysis are prescribed 1/2 therapeutic dose 2 times a day or a full dose once a day. Side effects On the part of the central nervous system (CNS), dizziness, headache, tingling in the fingers, drowsiness, anxiety, depression, insomnia, sleep disturbance; on the part of the digestive system, nausea, abdominal pain, anorexia, diarrhea, pain in the rectum or anus, constipation, dyspepsia, flatulence, vomiting, dryness of the oral mucosa, heartburn, loose stools, bitter taste in the mouth, ulceration of the oral mucosa, itching of the anus. On the part of the hematopoietic organs, leukopenia, thrombocytopenia, eosinophilia, neutropenia. on the part of the skin. , rash, erythema, urticaria. On the part of the sense organs, blurred visual perception. On the part of the musculoskeletal system, bursitis, swelling of the hands and feet. On the part of the cardiovascular system (CVS), myocardial infarction, palpitations. On the part of the urinary system, renal colic. Laboratory indicators: increased activity of AST, ALT, alkaline phosphatase, LDH, proteinuria, decreased hematocrit and Hb, increased urinary concentration blood insults, hypercreatininemia, glucosuria. Other hyperhidrosis, asthenia, back pain, fever, chills, chest pain, dysmenorrhea, edema, allergic reactions. Interaction with other drugs With the simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced. With the simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in blood plasma is noted. With the simultaneous administration of norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexones with metal ions (the interval between taking them should be at least 4 hours). With simultaneous administration of norfloxacin reduces the clearance of theophylline by 25%, therefore, with simultaneous use, the dose of theophylline should be reduced. The simultaneous administration of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates, anesthetics, heart rate, blood pressure, and ECG indicators should be monitored. Simultaneous use with drugs that lower the epileptic threshold can lead to the development of epileptiform seizures. Reduces the effect of nitrofurans. special instructions It should be used with caution in patients with epilepsy, convulsive syndrome of another etiology, with severe renal and hepatic impairment. During the period of treatment, patients should receive a sufficient amount of fluid (under the control of diuresis). Norfloxacin should be taken at least 2 hours before or 2 hours after taking antacids or preparations containing iron, zinc, magnesium, calcium, or sucralfate.

Prescription

Yes