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Active ingredient

Doxazosin - oral tablets: 1 pill contains doxazosin mesilate 2.43 mg (based on the base - 2 mg), as well as excipients (milk sugar, sodium glycolate, starch, Magnesium stearic acid, MCC, sodium lauryl sulfate); 10, 20, 30, 40 or 50 pieces per pack.

Mechanism of action

Hypotensive, vasodilator, lipid-lowering, antispasmodic. Doxazosin selectively blocks postsynaptic alpha1-adrenoreceptors. Due to the decrease in muscle tone of blood vessels, it reduces OPS and lowers blood pressure. Decreases plasma triglycerides, total cholesterol and HDL cholesterol. At the same time, there is a slight increase in the HDL coefficient in relation to total cholesterol (by 4-13%). Doxazosin inhibits platelet aggregation and increases the content of active plasminogen in the tissues. Reduces the tone of smooth muscle cells of the stroma and the capsule of the prostate gland, as well as the bladder neck. Doxazosin lowers resistance and pressure in the urethra, reduces the resistance of the internal sphincter.

Indications and usage

Arterial hypertension (monotherapy and in combination with other antihypertensive drugs: thiazide diuretics, beta-blockers, Calcium channel blockers or ACE inhibitors),benign prostatic hyperplasia (in the presence of arterial hypertension and with normal blood pressure).


Hypersensitivity, pregnancy, breastfeeding, age up to 18 years.

Adverse reactions

When using Doxazosin, especially at the beginning of treatment, orthostatic hypotension is most often observed, which in rare cases can lead to fainting. In order to prevent orthostatic hypotension, patients should avoid unexpected and abrupt changes in body position (moving from a prone position to a standing position). There may be: headache, dizziness, general feeling of weakness, increased fatigue, drowsiness, rhinitis, nausea. Patients with arterial hypertension are rarely observed: tachycardia, arrhythmia, chest pain, angina attacks, myocardial infarction, cerebrovascular disorders. There have been isolated cases of allergic reactions (skin rash, jaundice, thrombocytopenic purpura, elevated transaminase level, transyamnaz,) priapism, urinary incontinence, increased appetite, constipation, increased diuresis, myalgia, arthralgia.

Dosage and administration

Doksazozin accept inside, irrespective of meal, without chewing and washing down with enough water, once a day (in the morning or in the evening). The initial dose is 1 mg 1 time per day (before bedtime), after which the patient should stay in bed for 6-8 hours (the development of the “first dose” phenomenon, especially expressed against the background of prior diuretic administration) is possible.With a lack of therapeutic effect, the daily dose of Doxazosin is increased to 2 mg only after 1-2 weeks of continuous treatment, then with an interval of 1-2 weeks, the dose is increased by 2 mg to achieve the optimal therapeutic effect.

Doxazosin is carefully prescribed for pulmonary edema caused by aortic or mitral stenosis; failure of the right ventricle of the heart due to lung embolism or pericardial effusion; left ventricular failure with low filling pressure; cardiac output failure.

Storage conditions

The drug should be stored out of reach of children at a temperature not exceeding 25 ° C. Shelf life - 2 years.

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