EXFORGE PILLS 10MG + 160MG
EXFORGE PILLS 10MG + 160MG - 28 tabs
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Active ingredient and dosage form
Tablets, film coated:
1 pill contains Amlodipine 10 mg, valsartan 160 mg,
Excipients: microcrystalline cellulose, crospovidone, Magnesium stearate, colloidal silicon dioxide, hypromellose (hydroxypropyl methyl cellulose), titanium dioxide (E171), ferric oxide yellow (E172), macrogol 4000 (polyethylene glycol 4000), talc;
in the package 14 or 28 pcs.
Mechanism of action
Exforge is a combined antihypertensive drug containing active substances with a complementary mechanism for controlling blood pressure. Amlodipine, a derivative of dihydropyridine, belongs to the class of slow Calcium channel blockers (BCCA), valsartan - to the class of angiotensin II receptor antagonists. The combination of these components has a mutually complementary antihypertensive effect, which leads to a more pronounced decrease in blood pressure compared to that on the background of monotherapy with each drug.
Indications and usage
Arterial hypertension (for patients for whom combination therapy is indicated).
Hypersensitivity to the drug; pregnancy.
The safety of Exforge in patients with unilateral or bilateral stenosis of the renal arteries or stenosis of the artery of a single kidney, in patients after a recent transplantation of a kidney,as well as children and adolescents under 18 years of age has not been established.
Dosage and administration
Exforge should be taken orally with a small amount of water, 1 time per day. regardless of meal times.
The recommended daily dose of Exforge is 1 pill in a dose of 5/80 mg or 5/160 mg or 10/160 mg.
When prescribing to elderly patients, patients with primary or moderate renal impairment (CC> 30 ml / min), with impaired liver function or with liver diseases, with cholestasis, no changes in dosage regimen are required.
Respiratory: often - nasopharyngitis, flu; sometimes - cough, sore throat and larynx.
Special senses: rarely - visual disturbances, tinnitus; sometimes - dizziness associated with dysfunction of the vestibular apparatus.
From the side of the central nervous system and peripheral nervous system: often - headache; sometimes - dizziness, drowsiness, orthostatic dizziness, paresthesias; rarely - anxiety.
Since the cardiovascular system: sometimes - tachycardia, palpitations, orthostatic hypotension; rarely - syncopal state, pronounced decrease in blood pressure.
Gastrointestinal: sometimes - diarrhea, nausea, abdominal pain, constipation, dry mouth.
Dermatological reactions: sometimes - skin rash, erythema; rarely - hyperhidrosis, rash, pruritus.
Musculoskeletal system: sometimes - swelling of the joints, back pain, arthralgia; rarely muscle crampsfeeling of heaviness throughout the body.
Urogenital: rarely - pollakiuria, polyuria.
From the reproductive system: rarely erectile dysfunction.
Other: often - pastoznost, swelling of the face, peripheral edema, fatigue, flushing of the face, asthenia, feeling of heat.
In dry, the dark place at a temperature of no higher than 20 ° C.