PANANGIN PILLS

Active ingredient

1 pill contains potassium asparaginate (K+ = 36.2 mg) 158 mg, Magnesium asparaginate anhydrous (Mg++ = 11.8 mg) 140 mg;
Excipients: anhydrous colloidal silica; Povidone; magnesium stearate; talc; corn starch; potato starch; titanium dioxide; macrogol 6000; Eudragit E

Packing

50 pcs.

Mechanism of action

Antiarrhythmic, compensating for the deficiency of magnesium and potassium. 
Panangin is a source of potassium and magnesium ions. Warns or eliminates hypokalemia. Improves metabolism of the myocardium. Improves tolerance to cardiac glycosides. It has antiarrhythmic activity. Asparaginate transports potassium and magnesium ions and promotes their penetration into the intracellular space. Asparaginate enters the cells and is involved in metabolic processes. Magnesium ion plays an important role in maintaining the homeostasis of potassium and Calcium, has the properties of a calcium channel blocker, participates in many enzymatic reactions, the metabolism of proteins and carbohydrates.

Indications and usage

Heart failure, myocardial infarction, cardiac arrhythmias (predominantly ventricular arrhythmias), additional therapy for treatment with cardiac glycosides, hypokalemia, hypomagnesemia, insufficient intake of magnesium and potassium ions in the body when they are deficient in the diet.

Contraindications

Hypersensitivity, acute and chronic renal failure, Addison's disease, anuria, AV block II-III degree, cardiogenic shock, severe arterial hypotension, hyperkalemia, hypermagnemia, severe myasthenia, oliguria, hemolysis, disturbance of amino acid metabolism.

Dosage and administration

For angina pectoris (as an aid) Panangin is prescribed by mouth for 2 pills 3 times a day.
For heart rhythm disorders Panangin is administered intravenously slowly or in drops of 2 amp. / Day (morning and evening).
with prophylactic or maintenance treatment Panangin prescribed 1 pill 3 times / day. The duration of therapy is determined individually.

Adverse reactions

From the nervous system and sensory organs: fatigue, hyporeflexia, dizziness, heat sensation, paresthesia.
Since the cardiovascular system and blood (hematopoiesis, hemostasis): lowering blood pressure, ECG changes, myocardial conduction and cardiac rhythm, phlebitis, vascular spasm, vasodilation, vein thrombosis.
Respiratory: dyspnea.
On the part of the digestive tract: diarrhea, nausea, vomiting, dry mouth, rarely - abdominal pain, bleeding and ulceration of the intestine and gastric mucosa, perforation of the intestinal wall, flatulence, esophagus and duodenal ulcer.
Metabolism: hyperkalemia.
Musculoskeletal system: muscle weakness.
From the skin: itching, increased sweating.

Drug Interactions

It inhibits the absorption of oral forms of Tetracycline, iron salts and sodium fluoride (requires a 3-hour break between doses). Due to the presence of potassium in the drug, the risk of hyperkalemia increases (potassium levels in the blood plasma must be controlled) when combined with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, Heparin and NSAIDs, the inhibitory effect on intestinal motility increases. With the development of hyperkalemia may decrease the action of drugs digitalis.
Due to the presence of magnesium in the preparation, the neuromuscular blockade is enhanced when combined with anti-depolarizing muscle relaxants, CNS depression - when combined with drugs for anesthesia. Reduces the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin. Calcium preparations reduce efficacy, and calcitriol increases the level of magnesium in the blood plasma.

Storage conditions

At a temperature of 15–30 ° C.