NOLIPREL A FORTE PILLS 5MG/1.25MG
NOLIPREL A FORTE PILLS 5MG/1.25MG - 30 tabs
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Arginine 5 mg, Indapamide 1.25 mg;
Excipients: sodium carboxymethyl starch (type A), colloidal anhydrous silicon dioxide, lactose monohydrate, Magnesium stearate, maltodextrin.
14 and 30 pieces per pack.
Mechanism of action
Noliprel A forte is a combination antihypertensive drug containing Perindopril (an ACE inhibitor) and indapamide (a diuretic from the group of sulfonamide derivatives). Pharmacological action Noliprel due to a combination of the individual properties of each of the components. The combination of perindopril and indapamide enhances the action of each of them.
Noliprel A has a pronounced dose-dependent hypotensive effect on both systolic and diastolic blood pressure in the supine and standing position. The effect of the drug lasts for 24 hours. Persistent clinical effect occurs less than 1 month after the start of therapy and is not accompanied by tachycardia. Discontinuation of treatment is not accompanied by the development of withdrawal syndrome.
Noliprel reduces the degree of left ventricular hypertrophy, improves arterial elasticity, lowers round neck, does not affect lipid metabolism (total cholesterol, HDL, LDL, triglycerides) and does not affect carbohydrate metabolism (including in patients with diabetes mellitus).
Indications and usage
Essential arterial hypertension.
Hypersensitivity to perindopril and other ACE inhibitors;
Hypersensitivity to indapamide and sulfonamides;
Angioedema in history (including in patients receiving ACE inhibitors);
Renal failure severe (CC less than 30 ml / min);
Severe liver failure (including with encephalopathy);
Simultaneous administration of drugs that prolong the QT interval;
Pregnancy, lactation (breastfeeding).
The drug should be used with caution in bilateral renal artery stenosis or arterial stenosis of the only functioning kidney, in renal insufficiency, systemic connective tissue diseases (SLE, scleroderma), during therapy with immunosuppressants (risk of developing neutropenia, agranulocytosis), bone marrow hematopoietic suppression, diminished BCC, diuretic intake, salt-free diet, vomiting, diarrhea, hemodialysis), with cerebrovascular diseases, renovascular hypertension, diabetes mellitus, severe heart failure (stage IV), with hyperuricemia (especially with concomitant gout and urate nephrolithiasis), while taking potassium-sparing diuretics, potassium and lithium preparations, with blood pressure lability, during hemodialysis using high-flow membranes, during desensitization, after kidney transplantation, with aortic valve stenosis / hypertrophic cardiomyopathy,in lactose deficiency, galactosemia or glucose / galactose malabsorption syndrome, in elderly patients, in patients under the age of 18 years (efficacy and safety have not been established).
Dosage and administration
Adults, including elderly patients, are prescribed 1 pill per day, preferably in the morning.
The use of the drug Noliprel can cause a sharp decrease in blood pressure, especially when you first take the drug and during the first 2 weeks of therapy.
In the dark place at a temperature of no higher than 30 ° C.