HYZAAR FORTE PILLS 100MG/12.5MG COATED
HYZAAR FORTE PILLS 100MG/12.5MG COATED - 28tabs
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1 tab. contains Losartan potassium 100 mg, hydrochlorothiazide 12.5 mg
Mechanism of action
Hyzaar Forte - combination drug; has a hypotensive effect. It contains losartan, an antagonist of angiotensin II receptors (type AT1) and hydrochlorothiazide, a thiazide diuretic.
Indications and usage
Arterial hypertension. Reducing the risk of cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy.
Hypersensitivity, anuria, hypovolemia (including on the background of high doses of diuretics), hepatic and / or renal failure, pregnancy, lactation.
Pregnancy and Breastfeeding
Taking medicines directly acting on the RAAS in the II-III trimesters of pregnancy can lead to fetal death. In the event of pregnancy, abolition is indicated (thiazides penetrate through the BBB). In relation to healthy pregnant women, the use of diuretics is usually not recommended due to the risk of fetal and newborn jaundice and mother thrombocytopenia.Diuretic therapy does not prevent the development of toxicosis of pregnancy.
Dosage and administration
Hyzaar Forte is taken orally, 1 pill / day, regardless of the meal. The maximum dose - 2 pills 1 time / day. The maximum hypotensive effect develops within 3 weeks after the start of treatment.
Decreased blood pressure, dizziness, allergic reactions: angioedema (swelling of the face, lips and / or tongue), hyperkalemia, increased activity of hepatic transaminases.
There is no need for a special selection of the initial dose for elderly patients. Perhaps joint appointment with other antihypertensive drugs. May increase urea and creatinine concentrations in plasma in patients with bilateral renal artery stenosis or single renal artery stenosis. Hydrochlorothiazide can increase hypotension and water-electrolyte imbalance (decrease in BCC, hyponatremia, hypochloraemic alkalosis, hypomagneemia, hypokalemia), impair glucose tolerance, reduce Calcium excretion in urine and cause a transient slight increase in calcium concentration in plasma, increase concentration. provoke the occurrence of hyperuricemia and / or gout. Taking medicines directly acting on the RAAS in the II-III trimesters of pregnancy can lead to fetal death.In the event of pregnancy, abolition is indicated (thiazides penetrate through the BBB). In relation to healthy pregnant women, the use of diuretics is usually not recommended due to the risk of fetal and newborn jaundice and mother thrombocytopenia. Diuretic therapy does not prevent the development of toxicosis of pregnancy.
At the same time taking hydrochlorothiazide with ethanol, barbiturates, opioid analgesics increases the risk of orthostatic hypotension; oral hypoglycemic drugs and insulin may require dose adjustment of hypoglycemic agents; with other antihypertensive drugs, an additive effect is possible; with Kolestiramine and Kolestipol - violation of the absorption of hydrochlorothiazide. A single dose of colestyramine or colestipol may reduce the absorption of hydrochlorothiazide in the gastrointestinal tract by 85% and 43%, respectively. With simultaneous use of hydrochlorothiazide with GCS, ACTH, it is possible to increase the loss of electrolytes, aggravating hypokalemia; with pressor amines (norepinephrine, epinephrine), a slight decrease in the effect of pressor amines, which does not prevent their use; with non-depolarizing muscle relaxants (tubocurarine) - enhancing their action; with NSAIDs, it is possible to reduce diuretic, natriuretic, hypotensive action. Do not use simultaneously with lithium preparations, sincediuretics reduce renal clearance of lithium and increase the risk of intoxication.
Symptoms:Losartan - lowering blood pressure, tachycardia, bradycardia (as a result of vagal stimulation). Hydrochlorothiazide - loss of electrolytes (hypokalemia, hypochloremia, hyponatremia); dehydration (excess diuresis).
Treatment: symptomatic and supportive therapy. If the drug is taken recently, wash the stomach; if necessary, conduct correction of water and electrolyte disorders. Losartan and its active metabolites are not removed by hemodialysis.
The drug should be stored in a dry place inaccessible to children at a temperature up to 25 ° C.