LOSAREL PILLS 50MG
LOSAREL PILLS 50MG - 30 TABS
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Losartan Potassium 50 mg
Excipients: microcrystalline cellulose, lactose monohydrate, pregelatinized starch, anhydrous colloidal silicon dioxide, Magnesium stearate.
The composition of the film shell: hypromellose, hyprolosis, macrogol 400, titanium dioxide (E171), talc.
Mechanism of action
LOSAREL - antihypertensive agent. It is a non-peptidic blocker of angiotensin II receptors. It has a high selectivity and affinity for receptors like AT1 (with the participation of which the main effects of angiotensin II are realized). By blocking these receptors, Losartan prevents and eliminates the vasoconstrictor effect of angiotensin II, its stimulating effect on the secretion of aldosterone by the adrenal glands and some other effects of angiotensin II. It is characterized by a prolonged action (24 hours or more), due to the formation of its active metabolite.
Indications and usage
Reducing the risk of associated cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy, manifested by a decrease in the combined frequency of cardiovascular mortality, the incidence of stroke and myocardial infarction.
Kidney protection in patients with diabetes mellitus type 2 with proteinuria - slowing the progression of renal failure, manifested by a decrease in the frequency
hypercreatininemia, the incidence of end-stage CRF requiring hemodialysis or kidney transplantation,
mortality rates, as well as a decrease in proteinuria.
Chronic heart failure with treatment failure by ACE inhibitors.
Pregnancy, lactation, hypersensitivity to losartan.
Dosage and administration
The average dose for oral administration is 50 mg 1 time / day. If necessary, the dose can be reduced to 25 mg / day or increased to 100 mg / day, in the latter case it is possible to use 2 times / day.
Cardiovascular: dizziness, orthostatic hypotension.
Allergic reactions: angioedema (including swelling of the face, lips, pharynx, and / or tongue), urticaria.
Gastrointestinal: diarrhea, increased ALT activity.
From the side of the central nervous system: headache.
Other: renal dysfunction, myalgia.
With simultaneous use with diuretics in high doses, arterial hypotension is possible.
With simultaneous use with potassium preparations, potassium-sparing diuretics increases the risk of hyperkalemia.
With simultaneous use with Indomethacin may decrease the effectiveness of losartan.
There is a message about the development of lithium intoxication with simultaneous use of lithium carbonate.
With simultaneous use with orlistat decreases the antihypertensive effect of losartan, which can lead to a significant increase in blood pressure, the development of hypertensive crisis.
At simultaneous use with rifampicin the clearance of a losartan increases and its efficiency decreases.
At temperatures not above 25 ° C.