TERAFLEX CAPSULES

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TERAFLEX CAPSULES - 200 pcs

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Tradename

Teraflex.

Glucosamine + Chondroitin Sulfate.

Composition

1 capsule contains

glucosamine hydrochloride 500 mg,
chondroitin sodium sulfate 400 mg.

Excipients: stearic acid 10 mg, Magnesium stearate 5 mg, manganese sulfate 1 mg.

Gelatin capsule: gelatin 120 mg.

Transparent hard gelatin capsules No. 00. The contents of the capsules are white or white with a yellowish tinge of color with crystalline particles.

Reparation tissue stimulator.

Pharmacology

Stimulates the regeneration of cartilage tissue. Glucosamine and chondroitin sulfate are involved in the synthesis of connective tissue, helping to prevent the processes of cartilage destruction and stimulating tissue regeneration. The administration of exogenous glucosamine enhances the production of cartilage matrix and provides non-specific protection against chemical damage to cartilage. Another possible effect of glucosamine is to protect damaged cartilage from metabolic destruction caused by nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), as well as its own moderate anti-inflammatory effect.
Chondroitin sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronon, the synthesis of proteoglycans and type II collagen, and also protects hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase); maintains the viscosity of synovial fluid, stimulates the mechanisms of cartilage repair and inhibits the activity of those enzymes that break down cartilage (elastase, hyaluronidase). In the treatment of osteoarthritis, it relieves the symptoms of the disease and reduces the need for NSAIDs.

Glucosamine
Absorption. Bioavailability of glucosamine when taken by mouth is 25% (the effect of “first passage” through the liver).
Metabolism. After the oral dose has been absorbed, the radiolabeled glucosamine is first detected in the plasma and later penetrates the tissue. The greatest concentrations are found in the liver, kidneys and articular cartilage. About 30% of the accepted dose persists for a long time in the tissues of the bones and muscles.
Elimination. Excreted mainly by the kidneys in unchanged form; partially through the intestines. The half-life of the drug is 68 hours
Chondroitin sulfate
Absorption. When ingestion of chondroitin sulfate once at a dose of 0.8 g (or 2 times a day, 0.4 g) the plasma concentration increases over 24 hours. Absolute bioavailability is 12%.
Metabolism. Metabolized by desulfurization.
Elimination. Excreted by the kidneys.A half-life of 310 minutes.

Indications and usage

Degenerative-dystrophic diseases of the joints and spine: osteoarthrosis stage I - III, osteochondrosis.

Contraindications

Hypersensitivity, severe chronic renal failure, pregnancy, lactation, age up to 15 years.

Carefully
Diabetes mellitus, bleeding tendency, bronchial asthma.

Pregnancy and breastfeeding

Clinical data on the efficacy and safety of the drug Teraflex during pregnancy and lactation (breastfeeding) are missing.

Dosage and administration

Inside Adults and children over 15 years old are prescribed 1 capsule 3 times a day for the first three weeks; in the following days - 1 capsule 2 times a day, regardless of the meal, with a small amount of water. The recommended duration of treatment is from 3 to 6 months. If necessary, it is possible to conduct repeated courses of treatment, the duration of which is set individually.

Adverse reactions

Teraflex is well tolerated by patients. Dysfunction of the gastrointestinal tract (epigastric pain, flatulence, diarrhea, constipation), dizziness, headache, pain in the legs and peripheral edema, drowsiness, insomnia, tachycardia, allergic reactions are possible.

Overdosage

Symptoms: cases of overdose are unknown.With an overdose of chondroitin sulfate, hemorrhagic rash, nausea, vomiting are possible. Treatment: gastric lavage, symptomatic therapy.

Drug interactions

Improves the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins and chloramphenicol. The drug is compatible with NSAIDs and glucocorticosteroids. Chondroitin sulfate may enhance the effect of anticoagulants.

Special notes

With the appearance of undesirable effects on the gastrointestinal tract, the dose of the drug should be reduced by 2 times, and in the absence of improvement, cancel the drug.

Storage conditions

At a temperature not higher than 25 ºС.

Keep out of the reach of children.

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