GLAUPROST EYE DROPS 0.005% VIAL 2.5 ML

Latin name

Glauprost

Release form

Eye drops

Composition

1 ml of drops contains: latanoprost 50 mcg.
Excipients: disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, benzalkonium chloride, purified water.

Packaging

Bottle dropper 2.5 ml.

Mechanism of action

Glauprost - antiglaucoma drug. It is a prostaglandin F2α analogue and selective FP receptor agonist. It reduces intraocular pressure by increasing the outflow of aqueous humor, mainly through the uveoscleral route, as well as through the trabecular network. It does not have a significant effect on the production of aqueous humor and does not affect the hematophthalmic barrier. The reduction in intraocular pressure begins 3-4 hours after the administration of the drug, the maximum effect is noted after 8-12 hours, the effect lasts for at least 24 hours.

Indications

Open-angle glaucoma, increased intraocular pressure.

Contraindications

Hypersensitivity. With care: children's age.

Use during pregnancy and lactation

Perhaps if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Dosage and administration

In the conjunctival sac of the affected eye is instilled 1 drop 1 time / evening; when skipping a dose, the next one is administered as usual (i.e., the dose is not doubled).

Side effects

Foreign body sensation in the eye, conjunctival hyperemia, punctate epithelial erosion, macular edema (usually with aphakia or pseudo-акиphakia with a lens in the anterior chamber of the eye), increased pigmentation of the iris with color changes mainly in patients with mixed gray or yellow-brown) color of the iris and rarely with a uniform color of it (blue, gray, green, brown): the whole iris or its parts become more intense color; permanent heterochromia (in the treatment of one eye), a reversible increase in the palpebral fissure, skin rash.

Drug interaction

Beta-adrenergic blockers (timolol), adreno-mimetics (adrenaline dipivalyl), carbonic anhydrase inhibitors (acetazolamide), cholinomimetic (weaker) enhance the main effect. Pharmaceutically incompatible with thiomersal (precipitation possible).

Overdosage

Symptoms: irritation of the mucous membrane of the eye, conjunctival hyperemia or episclera.
Treatment: conducting symptomatic therapy.

Storage conditions

In the dark place at a temperature of 2-8 ° C. After opening - at a temperature not higher than 25 ° C for 4 weeks.

Shelf life

3 years.