AZARGA EYE DROPS 10MG + 5MG BOTTLE 5ML

Dosage form

Eye drops

Composition

1 ml.Azarga eye dropscontains brinzolamid 10 mg, Timolol (in the form of maleate) 5 mg;
Excipients: mannitol, disodium edetate, sodium chloride, purified water, benzalkonium chloride 50%, sodium hydroxide, tyloxapol.

Packing

Bottle of 5 ml.

Mechanism of action

Azarga eye drops - antiglaucoma drug.
Brinzolamide: is an inhibitor of carbonic anhydrase II. Due to the inhibition of carbonic anhydrase II, the formation of bicarbonate ions is slowed down, followed by a decrease in sodium and fluid transport, which leads to a decrease in the production of intraocular fluid in the ciliary body of the eye. The result is a reduction in intraocular pressure (IOP).
Timolol: a non-selective beta-adrenoreceptor blocker without sympathomimetic activity, does not have a direct depressive effect on the myocardium, does not possess membrane stabilizing activity. When applied topically AZARGA eye dropsreduce intraocular pressure by reducing the formation of aqueous humor and a small increase in its outflow.
The combined action of brinzolamide and timolol exceeds the effect of each substance separately.

Indications and usage

Azarga eye drops

Reduction of increased intraocular pressure in open-angle glaucoma and intraocular hypertension in patients in whom monotherapy was not sufficient to reduce intraocular pressure.

Contraindications

Azarga eye drops

• Individual hypersensitivity to the drug componentsAzarga eye drops.
• Bronchial asthma, bronchial asthma in history.
• Chronic obstructive pulmonary disease of severe course.
• Bronchial hyperreactivity.
• Sinus bradycardia.
• Atrioventricular block II-III degree.
• Severe heart failure.
• Cardiogenic shock.
• Allergic rhinitis heavy flow.
• Hypersensitivity to the group of beta-blockers.
• Hyperchosemic acidosis.
• Severe renal failure (creatinine clearance
• Closed angle glaucoma.
• Hypersensitivity to sulfonamides.
• Simultaneous use with oral carbonic anhydrase inhibitors.
• Pregnancy.
• Lactation period.
• Children's age up to 18 years.

Pregnancy and Breastfeeding

Azarga eye dropscontraindicated for use during pregnancy and lactation.

Dosage and administration

Azarga eye dropsapply topically. Shake the bottle before use. 1 drop in the conjunctival sac of the eye 2 times / day. After applying the drug Azarga eye dropsTo reduce the risk of systemic side effects, it is recommended that a finger lightly press on the projection area of ​​the lacrimal sacs at the inner corner of the eye for 1-2 minutes after the drug is installed - this reduces the systemic absorption of the drug.

Adverse reactions

Timolol: 
Local reactions: 1-10% of cases - blurred vision, pain in the eye, eye irritation, foreign body sensation; 0.1-1% of cases - corneal erosion, punctate keratitis, dry eye syndrome, eye discharge, itching in the eye, blepharitis, allergic conjunctivitis, effusion in the anterior chamber of the eye, conjunctival hyperemia, formation of crusts at the edges of the eyelids, asthenopia, feeling of discomfort in the eyes, itching, erythema of the eyelids, allergic blepharitis.
Systemic side effects:1-10% of cases - dysgeusia; 0.1-1% of cases - insomnia, decrease in blood pressure, chronic obstructive pulmonary disease, pain in the oropharynx, rhinorrhea, cough, dysplasia, lichen planus.
Brinzolamide: 
Local reactions: keratitis, keratopathy, increased excavation of the optic nerve head, defect of the corneal epithelium, increased intraocular pressure, deposits on the cornea, formation of corneal defects, corneal edema, conjunctivitis, inflammation of the meibomian glands, diplopia, photophobia, photopsy, reduction of visual acuity, insteria, deteroration eye hypesthesia, scleral pigmentation, subconjunctival cyst, increased tearing, blurred vision, eye swelling, eye allergic reactions, mydriasis, eyelid edema.
Systemic side effects: apathy, depression, decreased libido, nightmares, nervousness, drowsiness, motor dysfunction, amnesia, memory impairment, disturbances of the central nervous system.
Treatment: rinse immediately with water. Symptomatic and supportive therapy.Electrolyte levels and blood pH should be monitored. Hemodialysis is ineffective.

Special notes

Azarga eye dropscontraindicated in severe renal failure (creatinine clearance less than 30 ml / min).

Research on the interaction with other drugs was not conducted. Not recommended simultaneous use Azarga eye dropswith oral carbonic anhydrase inhibitors, as there is a possibility of increased systemic adverse reactions.

Overdosage

Azarga eye drops

Symptoms of overdose: electrolyte imbalance, development of acidosis, disorders of the central nervous system. Information about cases of overdose with local use Azarga eye drops are missing.
Treatment: rinse immediately with water. Symptomatic and supportive therapy. Electrolyte levels and blood pH should be monitored. Hemodialysis is ineffective.

Storage conditions

A drug Azarga eye dropsstored at a temperature of 2 ° to 30 ° C, out of the reach of children.

2 years.