PROTARGOL-LOR solution 200 mg №2

PROTARGOL-LOR PHARMSTANDARD tab. for application solution 200 mg No. 2 + vial. - DROPS.

Composition

For one tablet Active ingredient: silver proteinate (protargol) - 200.0 mg. Excipient: hydroxypropyl methylcellulose - 10.0 mg.

Dosage form

tablets for solution for topical use

Description

Round, flat-cylindrical tablets from brown to dark brown or almost black with a bluish tinge with an uneven surface color, with a chamfer and a risk.

Pharmacodynamics

When ingested, silver proteinate dissociates to form silver ions, which have an astringent, antiseptic and anti-inflammatory effect. Silver ions actively suppress the reproduction of infectious agents by binding their DNA. The mechanism of action is based on the fact that silver ions on the damaged mucous membrane precipitate proteins and form a protective film. At the same time, sensitivity decreases, blood vessels narrow (this leads to a decrease in edema) and the inflammatory process is suppressed. Silver ions also inhibit the growth of various bacteria. Active against gram-positive and gram-negative bacteria: B. cereus,

C. albicans, E. coli, R. aeruginosa. С.aureus, A.niger, S.abony and others.

Pharmacokinetics

When applied topically, it is practically not absorbed.

Indications for use

Symptomatic therapy of acute nasopharyngitis (runny nose), sinusitis.

Contraindications

Hypersensitivity to the components of the drug, atrophic rhinitis, pregnancy, breastfeeding, children under 3 years of age (for this dosage).

Use during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Use in children

Contraindicated in children under 3 years of age (for this dosage).

Side effects

- Allergic reactions: skin itching, irritation of the mucous membrane, urticaria; - sensation of burning and numbness; - dry mouth; - redness of the eyes; - anaphylactic shock; - angioedema; - atopic dermatitis. If any of the side effects indicated in the instructions worsen, the drug should be discontinued. If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Pharmacodynamic, pharmacokinetic interaction: not studied. Pharmaceutical interaction: salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with a solution of silver proteinate; a solution of silver proteinate is inactivated by alkaloid salts and organic bases (epinephrine). If you are using any of the above or other medicines (including over-the-counter medicines), consult your doctor before taking Protargol-Lor.

Dosage and administration

Locally in the form of a 2% solution. How to prepare a 2% solution: 1. Place one tablet of Protargol-ENT in a dark glass bottle. 2. Pour into the vial 10 ml (up to the level of the "shoulders" - narrowing of the vial) boiled water (pre-cooled to room temperature) or water for injection. 3. Close the bottle with a pipette cap, shake vigorously for 5 minutes, then leave for 10 minutes and then shake vigorously again for 5 minutes. The tablet should dissolve completely. Store the prepared solution for no more than 30 days in a place protected from light at a temperature not exceeding 25 ° C. Before using the drug Protargol-ENT, it is recommended to rinse and clean the nasal passages. Adults and children over 6 years old: 2-3 drops in each nostril 3 times a day. Children from 3 to 6 years old: 1-2 drops in each nostril 3 times a day for 5-7 days. The main effect of the drug will appear only 2-3 days after the first use. If symptoms persist or worsen for more than 5-7 days, it is recommended to consult a doctor. Use the drug only according to the method of application and in those doses that are indicated in the instructions for use. If necessary, please consult your doctor before taking the medicine.

Overdose

Symptoms: With the recommended route of administration, overdose is unlikely. Possible increased side effects. In case of accidental ingestion of a large amount of the drug, irritation of the gastrointestinal tract may occur. With prolonged uncontrolled use of the drug, it is theoretically possible that a very rare disease - argyrosis (staining in gray or bluish color of the skin and mucous membranes) may occur. Subject to the recommended dosing regimen, the risk of argyrosis is unlikely. Treatment. In case of severe irritation, burning, itching of the eyes, skin, mucous membranes, rinse with plenty of water for 15 minutes. Treatment is symptomatic.

special instructions

It is possible to stain discharge from the nose in gray or blue. Read the instructions for use carefully before you start using the drug. Save the instructions, you may need them again.

If you have any questions, please contact your doctor. The medicine you are taking is for you personally and should not be passed on to others as it may harm them further if they have the same symptoms as you.

Influence on the ability to drive vehicles and control mechanisms

The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release form

Tablets for solution for local use, 200 mg. Packing: 1 or 2 tablets in a blister pack made of polyvinyl chloride or PVC / PVDC film and printed lacquered aluminum foil. 1 blister pack, 1 dark glass bottle sealed with a polyethylene cap with first opening control, 1 pipette cap and instructions for use in a cardboard pack.

Terms of dispensing from pharmacies

Without recipe

Storage conditions

In original packaging, at a temperature not exceeding 25 °C. Ready solution in the place protected from light, at a temperature not above 25 °C. Keep out of the reach of children.

Best before date

2 years. Ready solution - 30 days. Do not use after the expiry date stated on the package.