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Trade name of the drug

Nazol® Advance.

International non-proprietary name


Dosage Form

Spray nasal dosed.


100 ml


1 dose


active substance:

oxymetazoline hydrochloride

0.05 g

0.025 mg




0.02 g

0.01 mg

camphor racemic

0.17 g

0.085 mg



0.17 g

0.085 mg


0.17 g

0.085 mg

disodium edetate dihydrate

0.1 g

0.05 mg

polysorbate 80

0.2 g

0.1 mg

propylene glycol

10 g

5 mg

sodium hydrophosphate dihydrate

0,006 g

0.003 mg

sodium dihydro-phosphate dihydrate

0.65 g

0.325 mg

hydrochloric acid, conc.

0.003 g

0.0015 mg

purified water

89.711 g

44.8555 mg


Clear liquid from colorless to light yellow color with a faint smell of menthol, eucalyptus and camphor.

Pharmacotherapeutic group

Decongestant - vasoconstrictor (alpha 2-adrenomimetik).

pharmachologic effect

Oxymetazoline belongs to the group of alpha stimulants for topical use. Has a vasoconstrictor effect. With the introduction of intranasal reduces swelling of the mucous membrane of the upper respiratory tract, which leads to the relief of nasal breathing and the opening of the mouths of the paranasal sinuses and Eustachian tubes.The effect of the drug is manifested in 10-15 minutes after application and lasts for 10-12 hours.

Indications for use

For relief of nasal breathing in case of “cold” diseases and viral infections of the upper respiratory tract, sinusitis, rhinitis of any etiology.


Hypersensitivity to the drug or its components, atrophic rhinitis, angle-closure glaucoma, marked atherosclerosis, conditions after transsphenoidal hypophysectomy, simultaneous use of monoamine oxidase inhibitors (including a period of 14 days after their withdrawal), children up to 6 years old, pregnancy, lactation period.


The drug should be used in patients with diseases of the cardiovascular system (arterial hypertension, coronary heart disease, chronic heart failure, tachycardia, arrhythmias), impaired carbohydrate metabolism (diabetes), hyperthyroidism, pheochromocytoma, chronic renal failure, hyperplasia prostate gland (urinary retention), with increased intraocular pressure, taking tricyclic antidepressants.

Use during pregnancy and during breastfeeding

Use during pregnancy and during breastfeeding is possible only in the case when the intended benefits to the mother outweigh the possible risk to the fetus or infant.

Dosage and administration


1 dose contains 0,025 mg oxymetazoline hydrochloride.

Adults and children over 12 years old - 2-3 doses in each nasal passage 2 times a day.

Children from 6 to 12 years old - 1 dose in each nasal passage 2 times a day.

Do not use the drug more than 2 times a day.

Duration of treatment:

Do not use the drug for more than 3 days. With frequent or long-term use of the drug, a feeling of difficulty in nasal breathing may appear again or worsen. If these symptoms appear, you should stop treatment and consult a doctor.

When injecting, do not tilt the head back and do not spray in the “lying” position.

Side effect

Burning or dryness of the nasal mucosa, dryness in the mouth and throat, sneezing, an increase in the volume of secretions released from the nasal cavity. After the effect of using the drug passes, a strong feeling of nasal congestion (reactive hyperemia).

Side effects caused by the systemic action of the drug: increased blood pressure, headache, dizziness, heartbeat, anxiety, nausea, insomnia. Benzalkoniya chloride, which is part of the drug, can cause irritation of the nasal mucosa. With prolonged use of the drug (more than 7 days) are possible: reactive hyperemia of the mucous membrane of the nasal cavity, atrophy of the mucous membrane of the nasal cavity, tachyphylaxis (a rapid decrease in therapeutic effect with repeated use).


In case of overdose or accidental intake of the drug inside, the following symptoms may develop: nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, increased blood pressure, shortness of breath, mental disorders,depression of the central nervous system (drowsiness, decrease in body temperature, bradycardia, decrease in blood pressure, respiratory arrest and coma). Treatment is symptomatic; in case of accidental ingestion - gastric lavage, intake of Activated carbon.

Interaction with other drugs

When used simultaneously with MAO inhibitors and tricyclic antidepressants, an increase in blood pressure may be observed. The drug slows down the absorption of local anesthetic drugs, lengthens their action. Co-administration of other vasoconstrictor drugs increases the risk of side effects.

special instructions

In the recommended dosage without consultation with the doctor, use no more than 3 days. Avoid contact with eyes. The drug has an effect on vision, possibly reducing the reaction rate.

To avoid the spread of infection, you must use the drug individually. With prolonged use (more than one week), the symptoms of nasal congestion may resume.

Influence on ability to drive machinery and other vehicles

During treatment, you should refrain from driving and practicing other potentially hazardous activities that require increased concentration or psychomotor speed, as the drug may cause dizziness and other side effects that may affect these abilities.

Release form

Spray nasal dosage of 0.025 mg / dose.On 10 ml (150 doses) in a bottle from high-density polyethylene with the batcher, a spray from polypropylene and a polyethylene protective cap. Label on the bottle. The bottle together with the instruction on a medical use is placed in a cardboard pack.

Storage conditions

At a temperature not higher than 25 ° С.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after expiration date.

Vacation conditions

Over the counter.


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