NUROFEN CANDLES FOR CHILDREN 60MG

Indications

As a symptomatic antipyretic in infectious and inflammatory diseases and conditions accompanied by fever, including with:

- acute respiratory diseases;

- flu;

- childhood infections;

- post-vaccination reactions.

As an analgesic for pain of low or moderate intensity, incl. with:

- headache;

- toothache;

- migraine;

- neuralgia;

- pain in the ears and throat;

- pain during sprains and other types of pain.

Dosage and administration

Nurofen® for children suppositories are specially designed for children. The drug is used rectally.

At fever and pain syndrome The dose of the drug depends on the age and body weight of the child. A single dose is 5-10 mg / kg 3-4 times / day. The maximum daily dose is 30 mg / kg.

Children aged 3-9 months (body weight 6-8 kg) appoint 1 supp. (60 mg) 3 times / day with an interval of 6-8 hours, but not more than 180 mg / day.

Children aged 9 months to 2 years (body weight 8-12 kg) appoint 1 supp. (60 mg) 4 times / day with an interval of 6 hours, not more than 240 mg / day.

At postimmunization fever children under 1 year prescribe 1 supp. (60 mg); children over 1 year old - 1 supp. (60 mg), if necessary, after 6 h, you can enter another 1 supp. (60 mg).

Duration of treatment: no more than 3 days as an antipyretic, no more than 5 days as an analgesic. If the fever persists, then consult a doctor.

Do not exceed the indicated dose of the drug.

Adverse effects

The risk of side effects can be minimized if the drug is used for a short time, at the minimum effective dose necessary to eliminate the symptoms.

Determination of the frequency of adverse reactions: very often (≥1 / 10), often (from ≥1 / 100 to <1/10), infrequently (from ≥1 / 1000 to <1/100), rarely (from ≥1 / 10 000 to <1/1000), very rarely (≤1 / 10 000).

Gastrointestinal: infrequently - abdominal pain, nausea, indigestion; rarely - diarrhea, constipation, flatulence, vomiting; very rarely - heartburn, peptic ulcer of the stomach, perforation of the wall or Gastrointestinal bleeding, ulcerative stomatitis, gastritis, exacerbation of ulcerative colitis and Crohn's disease, pancreatitis, duodenitis, esophagitis.

Liver and biliary tract: very rarely - abnormal liver function (jaundice, hepatitis, changes in liver function tests), hepatic-renal syndrome, hepatic necrosis, liver failure.

Allergic reactions: infrequently - skin rash, itching, urticaria; very rarely - angioedema, anaphylactoid reactions, anaphylactic shock, dyspnea, apnea, exacerbation of bronchial asthma, bronchospasm, serious forms of skin reactions, such as bullous reactions (Stevenson-Johnson syndrome, multiforme exudative erythema, toxic epidermal necrolysis, toxic epidermal necrolysis),

From the side of the central nervous system: infrequently - headache; very rarely - dizziness, nervousness, tinnitus,depression, drowsiness, insomnia, irritability, emotional instability, decreased concentration, seizures; extremely rare - aseptic meningitis.

Special senses: very rarely - reduced visual acuity, changes in color perception, toxic amblyopia.

Cardiovascular: swelling, tachycardia, increased blood pressure; rarely, cerebrovascular diseases, arterial hypotension, tachycardia, chronic heart failure in patients with impaired heart function.

Hemic and lymphatic: very rarely - disorders of hemopoiesis (anemia, neutropenia, aplastic anemia, hemolytic anemia, eosinophilia, decrease in hemoglobin and hematocrit, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis). The primary symptoms are: fever, sore throat, superficial oral ulcers, flu-like condition, severe exhaustion, nasal and skin bleeding, unexpected bleeding and bruising; reversible platelet aggregation, alveolitis, pulmonary eosinophilia, pancreatitis.

Urogenital: in the presence of impaired renal function, possible deterioration, cystitis, interstitial nephritis, nephrotic syndrome, oliguria, tubular necrosis, glomerulonephritis, changes in renal functional tests, polyuria; very rarely, acute renal failure, papillary necrosis (especially with prolonged use) associated with an increase in plasma urea concentration and edema.

From the reproductive system: possible violation of ovulation, a reversible decrease in fertility, which is restored when you stop using the drug.

Immune system: in the presence of systemic lupus erythematosus or mixed lesions of the connective tissue (Sharpe syndrome), the risk of aseptic meningitis is increased.

If these or other side effects appear, the patient should stop using the drug and consult a doctor.

Contraindications

- Hypersensitivity to Ibuprofen and other components of the drug;

- hypersensitivity to Acetylsalicylic acid or other NSAIDs;

- history of episodes of hypersensitivity (bronchial asthma, urticaria, rhinitis) in response to the use of acetylsalicylic acid (salicylates) or other NSAIDs;

- ulcerative lesion and / or bleeding from the gastrointestinal tract in the active phase or in history;

- confirmed hyperkalemia;

- blood diseases: hypocoagulation, leukopenia, hemophilia;

- severe liver failure;

- severe renal failure;

- severe heart failure;

- proctitis;

- III trimester of pregnancy;

- The body weight of the child is less than 6 kg;

- simultaneous use with other NSAIDs, including selective COX-2 inhibitors.

Use during pregnancy and lactation

If possible, you should avoid using the drug in the first 6 months of pregnancy.

Ibuprofen and its metabolites in very small concentrations can pass into breast milk,which does not entail special restrictions on the use or interruption of breastfeeding for the period of use of the drug.

Application for violations of the liver

Liver failure is a contraindication to the use of the drug.

Application for violations of kidney function

Renal failure is a contraindication to the use of the drug.

Use in children

Children aged 3-9 months (body weight 5.5-8 kg) appoint 1 supp. (60 mg) 3 times / day with an interval of 6-8 hours, but not more than 180 mg / day.

Children aged 9 months to 2 years (body weight 8-12.5 kg) appoint 1 supp. (60 mg) 4 times / day with an interval of 6 hours, not more than 240 mg / day.

At postimmunization fever children under 1 year prescribe 1 supp. (60 mg); children over 1 year old also - 1 supp. (60 mg), if necessary, after 6 h, you can enter another 1 supp. (60 mg).

Special notes

The possibility of using the drug Nurofen ® for children, the doctor decides individually in the following cases:

- If the child receives other analgesics;

- with instructions in the history of gastritis;

- with indications in the history of arterial hypertension and / or heart failure;

- in diseases of the liver or kidneys;

- in the presence of Helicobacter pylori infection;

- against the background of therapy with indirect anticoagulants, drugs to reduce blood pressure, GCS, antiplatelet agents, diuretics, lithium preparations, Methotrexate;

- in case of bronchial asthma, urticaria;

- in violation of defecation;

- with SLE or other autoimmune diseases of the connective tissue (increased risk of aseptic meningitis).

Overdosage

Symptoms: very rarely - abdominal pain, nausea, vomiting, diarrhea, gastrointestinal bleeding, headache, tinnitus, drowsiness, sudden agitation, disorientation, convulsions, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia.

Treatment: intake of enterosorbents, forced diuresis, symptomatic therapy. In case of accidental excess of the recommended dose, immediate consultation with a doctor is necessary.

Drug interaction

Simultaneous use of the drug Nurofen® for children with anticoagulants can lead to increased action of anticoagulants.

Use of the drug Nurofen® for children, along with diuretics and antihypertensive drugs reduces their effectiveness. In addition, diuretics can increase the nephrotoxicity of NSAIDs.

With simultaneous use with SCS increases the risk of ulcers and bleeding from the gastrointestinal tract.

When used simultaneously with selective serotonin reuptake inhibitors, the risk of gastrointestinal bleeding increases.

With simultaneous use with cardiac glycosides, it is possible to exacerbate heart failure, decrease the glomerular filtration rate and increase the concentration of cardiac glycosides in the blood plasma.

The simultaneous use of cyclosporine group drugs, tacrolimus increases nephrotoxicity.

With simultaneous use with zidovudine increases the risk of hematotoxicity.

With the simultaneous use of drugs of the quinolone group increases the risk of seizures.

With simultaneous use with mifepristone, the effectiveness of the latter decreases, therefore, NSAIDs can be taken no earlier than 8-12 days after the end of the use of mifepristone.

Nurofen® for children increases the concentration of Digoxin, phenytoin, methotrexate, lithium in the blood plasma while using it with these drugs.

Terms and conditions of storage

The drug should be kept out of the reach of children, in a dry place at a temperature not exceeding 25 ° C.