AUGMENTIN WED PILLS 1000MG + 62.5MG

Tablets with modified release film coated

Composition

1 pill contains Amoxicillin 1000 mg and clavulanic acid 62.5 mg

Packaging

28 pcs.

Mechanism of action

Augmentin CP is a combined broad-spectrum antibiotic resistant to b-lactamase, containing amoxicillin and clavulanic acid.
Amoxicillin is a semi-synthetic broad-spectrum antibiotic that is active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by b-lactamases, therefore microorganisms producing b-lactamase are not included in the spectrum of its antibacterial activity.
Clavulanic acid, a b-lactam compound, has the ability to inactivate a wide range of b-lactamases, enzymes that usually produce microorganisms that are resistant to penicillins and cephalosporins.
The presence of clavulanic acid in Augmentin composition protects amoxicillin from the destructive action of b-lactamase and expands the spectrum of its antibacterial activity with the inclusion of microorganisms, usually resistant to other penicillins and cephalosporins.
Augmentineffective against gram-positive aerobic microorganisms: Bacillis anthracis, Corynebacterium spp., Enterococcus faecalis, Enterococcus faecium, Listeria monocytogenes, Nocardia asteroides, Staphylococcus aureus, coagulase-negative staphylococci (including Staphylococcus epidermidis), Streptococcus spp. (including Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans);for gram-positive anaerobic microorganisms: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.;for gram-negative aerobic microorganisms: Bordetella pertussi spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica;for gram-negative anaerobic microorganisms: Bacteroides spp. (including Bacteroides fragilis), Fusobacterium spp.;for other microorganisms: Borrelia burgdorferi, Chlamydiae, Leptospira icterohaemorrhagiae, Treponema pallidum.

Indications and usage

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- infections of the upper respiratory tract and upper respiratory tract (including recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis and Streptococcus pyogenes;
- lower respiratory tract infections: exacerbations of chronic bronchitis, lobar pneumonia and bronchopneumonia, usually caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis;
- infections of the urinary tract: cystitis, urethritis, pyelonephritis, infections of the female genital organs, usually caused by species of the family Enterobacteriaceae (mainly Escherichia coli), Staphylococcus saprophyticus and species of the genus Enterococcus, as well as gonorrhea caused by Neisseria gonorrhoeae;
- infections of the skin and soft tissues, usually caused by Staphylococcus aureus, Streptococcus pyogenes and species of the genus Bacteroides;
- infections of bones and joints: osteomyelitis, usually caused by Staphylococcus aureus, with the need for long-term therapy;
- other mixed infections, such as septic abortion, obstetric sepsis, intra-abdominal infections.

Contraindications

- jaundice or abnormal liver function in the history of Augmentin's use;
- hypersensitivity to beta-lactam antibiotics (including penicillins and cephalosporins).
Carefully should be used for infectious mononucleosis, pregnancy, lactation, gastrointestinal diseases (including if there is a history of indications of transferred colitis associated with the use of penicillins), chronic renal failure.

Dosage and administration

The dosage regimen is set individually depending on the age, body weight, renal function of the patient, as well as the severity of the infection.
For optimal absorption and reduction of possible side effects from the digestive system, Augmentin is recommended to be taken at the beginning of a meal.
Treatment should not be continued for more than 14 days without revising the clinical situation.
If necessary, it is possible to conduct stepwise therapy (at the beginning of the intravenous injection of the drug with the subsequent transition to oral administration).

Adverse reactions

Determination of the incidence of side effects: very often (> 10%), often (> 1% and 0.1% and 0.01% andHemic and lymphatic: rarely, reversible leukopenia (including neutropenia), thrombocytopenia; very rarely - reversible agranulocytosis and hemolytic anemia, an increase in bleeding time and prothrombin time.
Allergic reactions: very rarely - angioedema, anaphylaxis, a syndrome similar to serum sickness, allergic vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematic pustus.
In case of any form of atopic dermatitis, treatment with Augmentin should be stopped.
Dermatologic: sometimes - skin rash, urticaria; rarely erythema multiforme.
From the side of the central nervous system: sometimes - dizziness, headache; very rarely - reversible hyperactivity and convulsions. Seizures can occur in patients with impaired renal function and in patients receiving the drug in high doses.
Gastrointestinal: very often - diarrhea (in adults); often - diarrhea (in children), nausea (more often when taking the drug in high doses), vomiting; sometimes dyspepsia; very rarely - discoloration of the surface layer of tooth enamel (in children taking the suspension).
Liver: sometimes with beta-lactam antibiotics, a moderate increase in ACT and / or ALT levels is observed (clinical significance not established); very rarely - hepatitis, cholestatic jaundice. These side effects are observed when taking other penicillins or cephalosporins.
The side effects of the liver are reversible, occurring during or shortly after the end of treatment. Children develop very rarely.Occur predominantly in men and elderly patients, and may be associated with long-term therapy.
In extremely rare cases, in patients with serious previous illnesses or in those who have received potentially hepatotoxic drugs, side effects can be severe and fatal.
Urogenital:very rarely - interstitial nephritis, crystalluria.
Effects due to microbiological effects: often - mucosal candidiasis; very rarely, pseudomembranous and hemorrhagic colitis.
When taking Augmentina side effects occur rarely and are predominantly light and transient.

Special notes

Before starting treatment with Augmentin, a detailed history should be collected regarding previous hypersensitivity reactions to penicillins, cephalosporins or other allergens.
Serious and sometimes lethal hypersensitivity reactions (anaphylactic reactions) to penicillins are described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to antibiotics in this group. In the event of an allergic reaction, it is necessary to discontinue treatment with Augmentin and initiate an alternative therapy. For serious hypersensitivity reactions, epinephrine (epinephrine) should be injected immediately. Oxygen therapy, intravenous steroids and airway management, including intubation, may also be required.
Augmentin should be avoided if infectious mononucleosis is suspected, since in such cases amoxicillin can cause a skin rash, which makes it difficult to diagnose the disease.
Use caution Augmentin in patients with impaired liver function.
The severity of side effects from the digestive system can be reduced by taking Augmentin at the beginning of a meal.
Oral care helps to prevent discoloration of teeth, because it is enough to brush your teeth.
In patients receiving Augmentin, an increase in prothrombin time is rarely observed, and therefore, with the simultaneous use of Augmentin and anticoagulants, it is necessary to conduct appropriate monitoring.
In patients with reduced diuresis, crystalluria occurs very rarely, mainly during parenteral therapy. When taking amoxicillin in high doses, it is recommended to take a sufficient amount of liquid and maintain adequate diuresis to reduce the likelihood of the formation of amoxicillin crystals.
Prolonged treatment with Augmentin may be accompanied by excessive growth of insensitive microorganisms.
In general, Augmentin is well tolerated and has a low toxicity peculiar to all penicillins. During prolonged therapy with Augmentin, it is recommended to periodically monitor the function of the kidneys, liver, blood formation.
Suspension contains aspartame, which is a source of phenylalanine, and therefore these dosage forms should be used with caution in patients with phenylketonuria.
In the medical literature there is no evidence of augmentin abuse and dependence on this drug.
Influence on ability to drive motor transport and control mechanisms
Augmentin does not adversely affect the ability to drive vehicles and work with machinery.

It is not recommended to apply Augmentin along with probenecid. Probenecid reduces the tubular secretion of amoxicillin, and therefore the simultaneous use of Augmentin and probenecid can lead to an increase and persistence in the blood levels of amoxicillin, but not clavulanic acid.
With the simultaneous use of Allopurinol and amoxicillin may increase the risk of allergic reactions. Data on the simultaneous use of Augmentin and allopurinol are currently not available.
Like other broad-spectrum antibiotics, Augmentin can reduce the effectiveness of oral contraceptives (this is necessary to inform patients).

Store in a dry place out of reach of children at a temperature not exceeding 25 ° C

2 years.