CIFRAN 1000 MG PILLS

Composition

NUMBER
Coated tablets: 1 pill contains Ciprofloxacin (in the form of monohydrate hydrochloride) - 250 or 500 mg;
10 pieces. in a blister, 1 or 10 blisters in a carton box.
Solution for infusion: 1 ml of solution contains ciprofloxacin (in the form of lactate) - 2 mg (1 bottle - 200 mg);
100 ml in a bottle, 1 bottle in a box.
Eye drops: 1 ml contains ciprofloxacin (in the form of hydrochloride) - 3 mg;
other ingredients: benzalkonium chloride;
10 ml in a bottle of dark glass, 1 bottle in a carton box.
DIGITAL OD
Tablets, film coated, prolonged action: white or almost white oval tablets, coated, with printed food inks "CIFRAN OD 500 mg", "CIFRAN OD 1000 mg".
1 pill contains ciprofloxacin 500 or 1000 mg;
in a blister, 5 pcs., in a box of 2 blisters.
DIGITAL ST
Coated tablets: 1 pill contains ciprofloxacin hydrochloride USP (equivalent to ciprofloxacin) 250 or 500 mg, Tinidazole BP 300 or 600 mg, respectively;
in the blister 10 pcs.; in a box of 1 or 10 blisters.

rr d / inf. - №014412 / 01-2002, 01.10.2002
tabl. - №014412 / 02-2002, 10/01/2002
Ch. drops - №014412 / 03-2002, 10/01/2002
Cifran OD - №014995/01-2003, 02.06.2003
Cifran ST - №015922/01, 31.08.2004

Mechanism of action

Antimicrobial broad-spectrum drug from the group of fluoroquinolones. The mechanism of action is associated with inhibition of the bacterial DNA gyrase enzyme and impaired DNA synthesis. Cifran increases the permeability of the cell wall of bacteria.It has a bactericidal effect on bacteria that are both in the breeding phase and in the resting phase.
Active against aerobic gram-negative bacteria: Escherichia coli, Klebsiella spp., Proteus spp. (indole-positive and indole-negative), Serratia spp., Enterobacter spp., Morganella morganii, Providencia spp., Citrobacter spp., Salmonella spp., Shigella spp., Yersinia enterocolitica, Vibrio cholerae, Vibrio parahaemothyo rythyo, us ter us us us us bac bac bac bac bac bac bac bac us us us us,, V V V V V je je us us us us us us ((((Indole-positive and indole-negative), Serratia spp., Enterobacter spp., Morganella morganii, Providencia spp., Citrobacter spp., Salmonella s. aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Acinetobacter anitratus, Branhamella catarrhalis, Gardnerella vaginalis, Moraxella spp., Pasteurella spp.; aerobic gram-positive bacteria: Staphylococcus aureus, including penicillinase-producing strains and methicillin-resistant strains, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Listeria monocytocycus intracellular bacteria: Chlamydia trachomatis, Mycoplasma hominis, Legionella spp., Brucella spp.
To drug resistant anaerobic bacteria: most strains of Clostridium spp., Fusobacterium spp., Actinomyces spp.
The drug has a long-term (up to 6 h) post-antibiotic effect, preventing the growth of bacteria in concentrations below BMD.
Cifran has no significant effect on anaerobic microorganisms and does not violate the normal intestinal microflora and vagina. Chromosome-mediated resistance to Cifran is rare, plasmid-mediated resistance is absent. Cross-resistance with other antibiotics other than fluoroquinolones is absent.
Cifran is active against gram-positive and gram-negative pathogens resistant to penicillins, cephalosporins and aminoglycosides.

DIGITAL ST - antimicrobial combination agent. Designed for the treatment of mixed infections caused by anaerobic and aerobic microorganisms and protozoa.
Tinidazole - effective against anaerobic microorganisms such as Clostridium difficile, Clostridium perfringens, Bacteroides fragilis, Peptococcus, Peptostreptococcus anaerobius. An anaerobic infection most often contains a mixture of anaerobic and aerobic bacteria. Therefore, in case of mixed anaerobic infection, an antibiotic active against aerobic bacteria is added to therapy. Tinidazole is also effective against the simplest (Trichomonas vaginalis, Lamblia intestinalis,Entamoeba histolytica.

Indications and usage

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- respiratory tract infections (pneumonia, bronchopneumonia, acute bronchitis, exacerbation of chronic bronchitis, pleurisy, empyema, lung abscesses, infected bronchiectasis, including in patients with cystic fibrosis);
- infections of the genitourinary system (acute and chronic pyelonephritis, prostatitis, cystitis, epididymitis, including complicated and recurrent);
- gonorrhea (urethritis, proctitis or pharyngitis, including those caused by resistant gonococci);
- infections of upper respiratory tract (including external and middle otitis, sinusitis, mastoiditis);
- infections of the skin and soft tissues (including infected ulcers, wounds and burns, abscesses, cellulites);
- gastrointestinal infections (including typhoid fever, peritonitis, intra-abdominal abscesses, cholangitis, cholecystitis, gallbladder empyema);
- infectious and inflammatory diseases of the pelvic organs (including salpingitis, endometritis);
- infections of bones and joints (including acute and chronic osteomyelitis, septic arthritis);
- septicemia, bacteremia and infections in immunocompromised patients;
- infectious and inflammatory diseases of the eye (for eye drops).
Prevention of postoperative infections (for iv administration).

Contraindications

 
- hypersensitivity to ciprofloxacin and other quinolones;
- pregnancy;
- lactation (breastfeeding);
- children's age up to 12 years.

Dosage and administration

Set individually depending on the severity of the infection, the type of pathogen, age, body weight and kidney function of the patient.
Inside with uncomplicated urinary tract infections appoint 250 mg every 12 hours
With prostatitis and complicated urinary tract infections - 500 mg every 12 hours.
For infections of the lower respiratory tract mild - 250 mg every 12 hours; moderate and severe - 500 mg every 12 hours; caused by resistant gram-positive microorganisms (Streptococcus spp.) - 750 mg every 12 hours.
With infections of upper respiratory tract - 500-750 mg every 12 hours
With infections of bones and joints - 500-750 mg every 12 hours
With gastrointestinal infections - 250-500 mg every 12 hours
With typhoid fever - 500 mg every 12 hours.
For gynecological infections - 500 mg every 12 hours.
With gonorrhea (acute, uncomplicated) - 500 mg once.
When expressed impaired renal function (CC less than or equal to 20 ml / min) the daily dose should be reduced by 2 times.
Children over 12 years old appoint 5-10 mg / kg body weight / day, divided into 2 doses.
Tablets are preferably taken before meals.

In the form of infusions for adults with urinary tract infections, and lower respiratory infections appoint 200 mg 2 times / day, slowly in / in. For other infections, 200 mg every 12 hours, slowly IV.
When bacteremia, septicemia - 400 mg (200 ml) every 12 hours.
When expressed impaired renal function (CC less than or equal to 20 ml / min) the daily dose should be reduced by 2 times.
Duration of infusion The figure in the dose of 200 mg is 60 minutes.
If necessary, after the on / in the introduction switch to oral administration of digital.
With septicemia, bacteremia and intra-abdominal infections after intravenous therapy, the drug is administered orally, 500-750 mg every 12 hours.
The duration of the course of treatment depends on the severity of the infection, the clinical dynamics and the bacteriological analysis data. In acute infections, the duration of therapy is 5-7 days. Treatment is continued for 3 days after the disappearance of the clinical symptoms of the infection.

Eye drops for diseases easy and moderate severity 1-2 drops are instilled into the lower conjunctival sac of the affected eye every 4 hours.
With severe 2 drops are instilled every hour until improvement is achieved, after which the dose may be lowered.

DIGITAL ST
Inside, after eating, drinking plenty of water. Do not crush, chew or destroy the tablet. Recommended dose: tablets with a ratio of ciprofloxacin / tinidazole 250/300 mg - 2 tablets 2 times a day, 500/600 mg - 1 pill 2 times a day.

From the digestive system: rarely - abdominal pain, vomiting, diarrhea; in some cases - increased activity of liver transaminases.
From the side of the central nervous system: rarely - headache, anxiety.
Local reactions: redness at the injection site, thrombophlebitis (with a / in the introduction).
Other: rarely - arthralgia, rash.
When used in recommended doses, side effects are unlikely.

Cifran is contraindicated for use during pregnancy and lactation (breastfeeding).

In connection with the threat of adverse reactions from the central nervous system in patients with epilepsy, bouts of convulsions in history, vascular diseases and organic brain lesions, ciprofloxacin should be used only for life reasons.
Excessive exposure to direct sunlight should be avoided. If a photosensitivity reaction occurs, it is recommended to stop using the drug.

In patients with allergic reactions to fluoroquinolone derivatives, these reactions to ciprofloxacin may occur.
With the use of almost all antibacterial drugs, including ciprofloxacin, the development of pseudomembranous colitis of varying severity (from mild to life-threatening) is possible. It should be borne in mind this diagnosis in the presence of intractable diarrhea in a patient taking antibacterial agents. If severe or prolonged diarrhea occurs during or after treatment, diagnosis of pseudomembranous colitis should be excluded, which requires immediate discontinuation of the drug and appropriate treatment.
In order to avoid the development of crystalluria, it is unacceptable to exceed the recommended daily dose, in addition, sufficient fluid intake and maintenance of acidic urine is necessary.
If there is pain in the tendons or the first signs of tendovaginitis, treatment should be stopped.
Due to the fact that antacids containing Magnesium hydroxide and / or aluminum hydroxide can slow down the absorption of ciprofloxacin, Cifran should be administered 1-2 hours before and at least 4 hours after taking these drugs.
When using eye drops and other ophthalmic drugs, the interval between their administration should be at least 5 minutes.
Use in pediatrics
Purpose Digital to children is possible only if the intended benefit exceeds the risk of side effects.

Treatment: there is no specific antidote. Symptomatic therapy: induction of vomiting or gastric lavage; carrying out measures for adequate hydration of the body (infusion therapy), maintenance of supporting therapy.
Only minor amounts of ciprofloxacin (<10%) can be removed with hemo-and peritoneal dialysis.

Ciprofloxacin
With simultaneous use of digital and theophylline, the concentration of theophylline in the blood plasma may increase (the content of theophylline in the blood plasma should be monitored and, if necessary, the dosage regimen should be adjusted).
Antacids containing magnesium or aluminum hydroxide, reduce the absorption of ciprofloxacin (you should exclude the simultaneous use of these drugs).
Probenecid reduces renal excretion of ciprofloxacin.
Absorption of ciprofloxacin decreases after cytotoxic therapy with antitumor and immunosuppressive drugs.
NSAIDs increase the side effects of ciprofloxacin on the central nervous system. In patients receiving therapy with ciprofloxacin and phenytoin, variability (decrease or increase) of plasma phenytoin levels was noted.
Sucralfate reduces the absorption of ciprofloxacin (due to the release of aluminum ions in the stomach). Quinolone derivatives enhance the effects of oral anticoagulants such as Warfarin and its derivatives (regular blood clotting should be done regularly).
In rare cases, the combined use of ciprofloxacin with glyburide can lead to severe hypoglycemia.
H antagonists2 Histamine receptors do not significantly affect the bioavailability of ciprofloxacin.
When combined with Metronidazole , no changes in plasma concentrations of drugs were detected.
Due to a decrease in the activity of microsomal oxidation processes in hepatocytes, it increases the concentration and lengthens T1/2 xanthines (for example, caffeine), oral hypoglycemic drugs.
Didanosine reduces the absorption of ciprofloxacin due to the formation of complexes with didanosinealuminum and magnesium salts.
Metoclopramide accelerates absorption, which reduces the time to reach Cmax ciprofloxacin. Co-administration of uricosuric drugs leads to a slower elimination (up to 50%) and an increase in the plasma concentration of ciprofloxacin.
When combined with other antimicrobial agents (beta-lactams, aminoglycosides, Clindamycin , metronidazole), synergism is usually observed; It can be successfully used in combination with azlocillin and ceftazidime for infections caused by Pseudomonas spp., with mezlocillin, azlocillin and other beta-lactam antibiotics - for streptococcal infections; with isoxazolpenicillins and Vancomycin - for staphylococcal infections; with metronidazole and clindamycin - for anaerobic infections.
Enhances the nephrotoxic effect of cyclosporine, an increase in serum creatinine is noted (such patients need to control this indicator 2 times a week).
Tinidazole.
Enhances the effect of indirect anticoagulants (to reduce the risk of bleeding, reduce the dose by 50%) and the effect of ethanol.
Compatible with sulfonamides and antibiotics (aminoglycosides, Erythromycin , rifampicin, cephalosporins).
Not recommended with ethionamide.
Phenobarbital accelerates metabolism.

The drug should be stored in a dry, dark place at temperatures not above 25 ° C.
Pharmacy sales terms
The drug is available on prescription.