NORCOLUT PILLS 5MG

Active ingredient and dosage form

1 pill contains 5 mg of norethisterone;
in vials of 20; in the box 1 bottle.

Mechanism of action

The active ingredient of Norcolut - norethisterone is primarily a progestin-type norsteroid. Compared with other known progestogens, the drug, although not among the most active progestogens, its properties are still unusually favorable for therapy.

In the so-called "delay of mensis" (delayed menstruation) test, used to determine the effectiveness of gestagens, the drug shows the properties of weak gestagens. The compound turned out to be a progestive medium-intensity steroid when tested by Hammerstein, as well as in a Clauberg test that measures the dose required for endometrial transformation.

In contrast to many progestin compounds, norethisterone has a pronounced anti-estrogenic character, and unlike other derivatives of nortestosterone in the body, only a small part of the compound is converted into estrogen.

At the same time, Paulsen observed gynecomastia in men under the influence of norethisterone, and an increase in mammary glands in women. In addition to the main progestogenic effect, a weak androgenic property of the compound was also determined.According to clinical and pharmacological studies, norethisterone blocks the production of follicle-stimulating hormone (FSH) and hormone of the corpus luteum (LH), reduces the synthesis of steroids by the corpus luteum.

Norethisterone, which possesses mainly a gestagenic property, exhibits a significant antiestrogenic and minimal estrogenic and androgenic effect, can be very widely used in the field of obstetrics and gynecology.

Indications and usage

Premenstrual syndrome, mastodinia, cycle disorders, accompanied by shortening of the secretion period, dysfunctional uterine bleeding, cystic glandular endometrial hyperplasia, endometriosis, adenomyosis, termination and prevention of lactation, postpone menstruation, menopause, in case of individual need oral contraception.

Contraindications

Predisposition to thrombosis, hepatitis, disorders of the hepatic function, malignant tumors of the breast and genital organs.

Dosage and administration

In case of premenstrual syndrome, mastodynia, and disordered cycles 1-2 pills are prescribed starting from the 16th day of the cycle to the 25th day of the cycle; this dosage may be supplemented with estrogen.

With dysfunctional uterine bleeding, cystic glandular hyperplasia of the endometrium (if the functional origin of the bleeding is confirmed by histological analysis carried out in a 6-month period), 1-2 pills per day are given for 6-12 days to stop the bleeding.To prevent relapse from the 16th day of the cycle to the 25th day of the cycle, 1-2 pills per day are prescribed, usually together with estrogen. In the case of a malignant process, Norcolut therapy is not used.

In case of endometriosis, adenomyosis starting from the 5th day and ending with the 25th day of the cycle, apply 1 pill per day for 6 months or continuously from the 5th day of the cycle 1/2 pill per day, increasing the dose by 1/2 pill every 2— 3 weeks, for 4-6 months.

To stop lactation in 1-3 days, 4 tablets, in 4-7 days, 3 tablets, on 8-10 days, 2 tablets. When menopausal symptoms are prescribed for a long time (months), 1 pill per day, or, in case of failure, is used in combination with 25-50 μg of ethinyl estradiol. For oral contraceptive use, 1 / 4–1 / 2 pills of Norcolut and 0.05 mg of ethinyl estradiol are used starting from the 5th day of the cycle for 21 days, then after a 7-day break, the course is repeated. If necessary, a 2-phase contraceptive dosage is prescribed from the 5th day of the cycle for 1/4 pills of Norcolut for 10 days, then 1/2 pills of Norcolut and 0.05 mg of ethinyl estradiol for 11 days.

For postponing menstruation treatment begins 8 days before the expected menstruation and lasts for 12 days: 2 pills of Norcolut are prescribed per day, this dosage provides approximately 7–8 days delay of menstruation.

Adverse reactions

Rarely encountered and in further cycles passing: nausea, gastrointestinal complaints, extraordinary bleeding, sometimes edema, allergic skin reaction, paresthesia, weight change, fatigue.

Drug Interactions

Drugs that activate microsomal liver enzymes (barbiturates, etc.), accelerate the metabolism and weaken the effect; on the contrary, inhibitors (cimetidine, etc.) - strengthen it.

Storage conditions

The drug should be stored in a dry place at a temperature of 15-30 ° C, out of the reach of children.

Norkolut