PHOSPHO-SODA 45ML

Fl 45ml number 2

Means for the treatment of the gastrointestinal tract

Mechanism of action

Laxative drug with osmotic properties.

The mechanism of action of the drug is based on the increase through osmotic processes of water retention in the lumen of the small intestine. The accumulation of fluid in the ileum leads to increased motility and subsequent intestinal cleansing.

Pharmacokinetics

The drug has only a local effect, so pharmacokinetic studies are not considered necessary. Sodium phosphate is poorly absorbed from the gastrointestinal tract, however, a small absorption of sodium ions and phosphates takes place and is dose-dependent.

Indications and usage

- preparation for endoscopic or radiographic examination of the colon;

- preparation for surgery on the colon.

The drug is used in adults and adolescents over the age of 15 years. Dose adjustment for elderly patients is not required.

Start taking Fleet Phospho-soda should be on the day preceding the prescribed endoscopic or radiological procedure. If the procedure is scheduled for noon, it is recommended that you follow the instructions for your morning appointment.If the procedure is scheduled for the afternoon, it is recommended that you follow the instructions for the daily appointment.

Morning appointment

Day before the procedure

At 7 o'clock in the morning, instead of breakfast, drink at least 1 cup of "light liquid" (including soups free from solid particles, fruit juices without pulp, tea and coffee, transparent carbonated and non-carbonated non-alcoholic drinks) or water.

The first dose should be taken immediately after breakfast. In half of a glass (120 ml) of cold water, the contents of 1 bottle (45 ml) should be dissolved. Drink the finished solution and drink one (or more) glasses (240 ml) of cold water.

At 13 o'clock, instead of lunch, you should drink at least 3 glasses (720 ml) of "light liquid" or water.

At 19 h instead of dinner, drink at least 1 cup of "light liquid" or water.

A second dose of the drug should be taken immediately after dinner. In half of a glass (120 ml) of cold water, the contents of the second bottle (45 ml) should be dissolved. Drink the finished solution and drink one (or more) glasses (240 ml) of cold water.

If desired, you can drink a larger volume of fluid. “Light liquids” and water can be drunk until midnight.

Day appointment

Day before the procedure

At 13 o'clock during lunch you can easily eat. After lunch, you can not eat any solid food.

At 19 h instead of dinner you should drink 1 cup of "light liquid" or water. If desired, you can drink a larger volume of fluid.

The first dose of the drug should be taken immediately after dinner.In half of a glass (120 ml) of cold water, the contents of the second bottle (45 ml) should be dissolved. Drink the finished solution and drink one (or more) glasses (240 ml) of cold water. If desired, you can drink a larger volume of fluid.

During the evening, you need to drink at least 3 glasses of "light liquid" or water.

Procedure day

At 7 o'clock in the morning instead of breakfast should drink 1 cup of "light liquid" or water. If desired, you can drink a larger volume of fluid.

A second dose of the drug should be taken immediately after breakfast. In half of a glass (120 ml) of cold water, the contents of the second bottle (45 ml) should be dissolved. Drink the finished solution and drink one (or more) glasses (240 ml) of cold water.

Water and "light liquids" can be consumed up to 8h.

Usually this drug causes stool for half an hour to 6 hours.

On the part of the digestive system: nausea, vomiting, abdominal pain, bloating, diarrhea; very rarely - with endoscopy, on the sigmoid and rectal mucosa, single or multiple autophobia-like formations can be observed (clinically insignificant, spontaneously disappear without treatment).

From the side of the central nervous system: asthenia, weakness, headache, dizziness.

On the part of metabolism: in individual patients from risk groups - dehydration and / or electrolyte imbalance (including hyperphosphatemia, hypocalcemia, hypokalemia, hypernatremia, acidosis).

Other: allergic reactions.

Contraindications

Do not use the drug in patients with the following diseases, conditions or suspicions on them:

- partial or complete intestinal obstruction;

- violation of the integrity of the intestine;

- megacolon (congenital or acquired);

- acute inflammatory bowel disease;

- heart failure;

- renal failure;

- the presence of nausea, vomiting, pain in the abdominal cavity;

- children's and teenage age up to 15 years;

- hypersensitivity to the drug.

Pregnancy and breastfeeding

Do not use Phospho Flit-soda during pregnancy, because there is not enough reliable information about the ability of the drug to toxicly affect the fetus and / or cause its incorrect formation.

Since sodium phosphate is excreted in breast milk, breastfeeding should be abandoned immediately after taking the first dose of the drug and for the next 24 hours after taking the last dose.

Application for violations of kidney function

The use of the drug is contraindicated in renal failure.

The drug should not be used as a treatment for constipation.

With caution should use the drug in elderly patients, weakened, with reduced kidney function, heart disease, colostomy, on a diet low in salt, because there is a likelihood of hyperphosphatemia, hypocalcemia, hypokalemia, dehydration against the background of hypernatremia, acidosis.

The patient should be warned of the possibility of frequent loose stools.

Very rarely, endoscopy on the sigmoid and rectal mucosa showed single or multiple autoform changes: lymphoid follicles, discrete formations of an inflammatory nature, or changes caused by the preparation. These abnormalities are not clinically significant and spontaneously disappear without treatment.

Rarely, prolongation of the QT interval on an ECG may occur as a result of electrolyte imbalance of the type of hypocalcemia or hypokalemia.

Influence on ability to drive motor transport and control mechanisms

The drug does not affect the ability to drive vehicles and control mechanisms.

Overdosage

Cases of death due to hyperphosphatemia with concomitant hypocalcemia, hypernatremia and acidosis have been described, after using the drug in high doses in children and patients with constipation.

At the same time, there are cases of complete recovery after an accidental overdose of the drug in children or patients with constipation (one of them received a 6-fold dose of the drug).

Drug Interactions

The drug should be used with caution in patients taking Calcium channel blockers, diuretics, lithium-based drugs and other drugs that can affect electrolyte levels, as there is a likelihood of hyperphosphatemia, hypocalcemia, hypokalemia, and dehydration due to hypernatremia and acidosis.

In the period of taking the drug Flit Phospho-soda, it is possible to delay or stop the absorption of drugs in the gastrointestinal tract. The effect of regularly taken medications (including antibiotics, oral contraceptives, antiepileptic drugs and hypoglycemic agents) may be reduced or absent altogether.

The drug is approved for use as a means of OTC.

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C. Shelf life - 3 years.