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COSMETIC BRANDS
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COSMETIC BRANDS
BONEFOS 800MG PILLS
BONEFOS 800MG PILLS - 60 tabs
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Indications and usage
Hypercalcemia due to malignant tumors;
osteolytic metastases of malignant tumors and myeloma (multiple myeloma);
prevention of the development of bone metastases of primary breast cancer.
Contraindications
Hypersensitivity to clodronic acid, other bisphosphonates, or any components that make up the preparation;
pregnancy;
breastfeeding period;
concomitant therapy with other bisphosphonates;
children's age (there is no clinical experience).
Dosage and administration
Inside, Bonefos capsules of 400 mg should be swallowed without chewing (table of 800 mg for the convenience of reception can be divided into 2 parts, which should be taken at the same time, but not grind or dissolve). The dose of Bonefos 1600 mg is preferable to take once in the morning on an empty stomach, with a glass of water, after which you should refrain from eating food and other drugs for 2 hours (except for ordinary water).Dose Bonefos more than 1600 mg is prescribed in 2 doses: the first - as recommended above, the second - between meals, 2 hours after or 1 hour before eating, drinking or taking other drugs.
With hypercalcemia, 2400–3200 mg / day in 2 divided doses with a gradual decrease to a maintenance dose of 1600 mg / day; with osteolytic bone changes due to malignant tumors without hypercalcemia - an initial dose of 1600 mg / day, if necessary - up to 3600 mg / day (not more); in patients with signs of renal failure - no more than 1600 mg.
Adverse reactions
From the side of electrolyte balance: asymptomatic hypocalcemia is possible, very rarely - hypocalcemia, accompanied by clinical manifestations.
On the part of the gastrointestinal tract: sometimes - nausea, vomiting, diarrhea.
On the part of the endocrine system: it is possible to increase the level of parathyroid hormone in the blood serum, usually accompanied by a decrease in the level of Calcium in the serum.
On the part of the liver: an increase in the activity of aminotransferases is possible.
On the part of the kidneys: rarely - an increase in serum creatinine and proteinuria; acute renal failure, which may develop after a quick injection of the drug.
On the part of the skin: occasionally there are skin reactions, according to the clinical picture, corresponding to hypersensitivity reactions.
On the part of the respiratory system: in patients with bronchial asthma, with a hypersensitivity to Acetylsalicylic acid in history, possible violations of respiratory function.
Special notes
Bonefos should not be taken with milk, food, or with preparations containing calcium or other divalent cations, since they all interfere with the absorption of clodronate. The prepared solution for infusion should be used within 12 hours.
Storage conditions
In a dry, dark place at a temperature of no higher than 25 ° C.
Bonefos