PAPAVERINE HYDROCHLORIDE AMPOULES 2% 2 ML
PAPAVERINE HYDROCHLORIDE AMPOULES 2% 2 ML - 10PCS
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Solution for injection 2%
1 ml of solution contains 20 mg of papaverine hydrochloride.
10 ampoules of 2 ml.
Mechanism of action
Papaverine hydrochloride - myotropic antispasmodic. It has a hypotensive effect. Inhibits phosphodiesterase, causes the accumulation of cyclic 3`, 5`-AMP in the cell and a decrease in Calcium content; reduces the tone and relaxes the smooth muscles of internal organs (GIT, respiratory and urogenital system) and blood vessels. Causes dilation of arteries, contributes to increased blood flow, incl. cerebral In large doses, reduces the excitability of the heart muscle and slows intracardiac conduction. The effect on the central nervous system is mild, but in high doses it has a sedative effect.
Indications and usage
Spasm of smooth muscles of the abdominal organs (cholecystitis, pylorospasm, spastic colitis, renal colic);
peripheral vasospasm (endarteritis);
spasm of cerebral vessels;
angina (as part of complex therapy);
Hypersensitivity, AV blockade, glaucoma, abnormal liver function, advanced age (risk of hyperthermia), children's age (up to 6 months).
Pregnancy and Breastfeeding
During pregnancy and lactation, the safety of the drug has not been established.
Dosage and administration
P / C, in / m - 1-2 ml of 2% solution (20-40 mg) 2-4 times a day; in / in, slowly 20 mg with a preliminary dilution in 10-20 ml of 0.9% sodium chloride solution. For elderly patients, the initial single dose is not more than 10 mg.
For the skin: allergic reactions.
On the part of the digestive tract: constipation, increased activity of "liver" transaminases.
Since the cardiovascular system: atrioventricular block, ventricular premature beats, lowering blood pressure.
From the hemopoietic system: eosinophilia.
From the side of the central nervous system: drowsiness.
With caution and in small doses should be used in elderly and debilitated patients, as well as in patients with traumatic brain injury, impaired liver and kidney function, hypothyroidism, adrenal insufficiency, prostatic hypertrophy, with supraventricular tachycardia and shock.
In / in should be entered slowly and under the supervision of a physician.
During the period of treatment should be excluded alcohol.
Reduces the effect of dopegita. When smoking is reduced.
Symptoms of overdose: diplopia, weakness, low blood pressure, drowsiness.
Treatment: symptomatic (maintenance of arterial pressure).
Store in a dark place.