Clodifen Neuro tablets

Release form

Capsules

Pharmacological effect

Diclofenac absorption is fast and complete. Plasma concentration is linearly dependent on the dose taken. Bioavailability is about 50%.

Plasma protein binding - more than 99% (most of it binds to albumin).

Approximately 60% of the dose is excreted as metabolites by the kidneys, less than 1% is excreted in the urine unchanged, the rest is excreted as metabolites in the bile.

The vitamins that make up Clodifen Neuro are water-soluble, which excludes the possibility of their accumulation in the body.

Thiamine and pyridoxine are absorbed in the upper part of the small intestine, metabolized in the liver and excreted by the kidneys (about 8-10% - unchanged). The degree of absorption depends on the dose; in case of an overdose, the excretion of thiamine and pyridoxine through the intestine is significantly increased.

The absorption of cyanocobalamin depends to a large extent on the presence of an intrinsic factor in the body (in the stomach and upper part of the small intestine); further delivery of the vitamin to the tissue is determined by the transport protein transcobalamin. After metabolism in the liver, cyanocobalamin is excreted mainly in the bile, the degree of excretion by the kidneys is variable - from 6 to 30%.

Indications

The indications for the use of the drug Clodifen Neuro are:

- pain syndrome in inflammation of a non-rheumatic nature (after injuries, surgical and dental interventions, in gynecological diseases - primary algomenorrhea, adnexitis, in inflammatory diseases of the ENT organs - pharyngitis, tonsillitis, otitis media),

- inflammatory and degenerative diseases of the spine and joints (rheumatoid arthritis, ankylosing spondylitis - ankylosing spondylitis, spondyloarthritis,

spondyloarthrosis, osteoarthritis),

- neuritis and neuralgia (cervical syndrome, lumbago, sciatica),

- acute gouty arthritis,

- rheumatic diseases of the periarticular soft tissues.

Contraindications to the use of the drug

Clodifen Neuro are: hypersensitivity to the components of the drug, gastric ulcer and 12 duodenal ulcer, III trimester of pregnancy, children under 12 years of age.

Method of administration and dosage

Clodifen Neuro capsules should be taken orally with meals, without chewing and drinking plenty of fluids.

For adults, the drug is prescribed 1 capsule 3 times a day at the beginning of treatment, as a maintenance dose, 1 capsule 1-2 times a day. The duration of therapy depends on the nature and severity of the disease.

Prescription