EUTIROX PILLS 125MCG

Indications

- euthyroid goiter;

- hypothyroidism;

- after resection of the thyroid gland as a replacement therapy and for the prevention of goiter recurrence;

- thyroid cancer (after surgical treatment);

- diffuse toxic goiter after reaching the euthyroid state of thyreostatics (as a combination therapy or monotherapy);

- as a diagnostic tool when conducting a thyroid suppression test.

Dosing regimen

The daily dose is determined individually depending on the evidence.

Eutirox® in a daily dose taken orally in the morning on an empty stomach, at least 30 minutes before a meal, drinking a pill with a small amount of liquid (half a glass of water) and not chewing.

When conducting hypothyroidism replacement therapy at patients under the age of 55 in the absence of cardiovascular diseases Eutirox ® prescribed in a daily dose of 1.6-1.8 mg / kg of body weight; at patients older than 55 years or with concomitant cardiovascular diseases - 0.9 mcg / kg body weight.

With significant obesity, dose calculation should be done on "ideal weight".

At hypothyroidism replacement therapy initial dose for patients under the age of 55 years (in the absence of cardiovascular diseases) for women it is 75-100 mcg / day, for men - 100-150 mcg / day. For patients older than 55 years or with concomitant cardiovascular diseases the initial dose is 25 mcg / day; increase the dose should be 25 mcg with an interval of 2 months to normalize the level of TSH in the blood; when symptoms or deterioration of the cardiovascular system occur, correct the appropriate therapy.

At severe long-existing hypothyroidism treatment should begin with extreme caution with small doses - 12.5 mg / day. The dose is increased to maintenance at longer intervals - at 12.5 mcg / day every 2 weeks - and the level of TSH in the blood is determined more often.

At treatment of congenital hypothyroidism at children doses of the drug depend on age.

The daily dose of Eutirox is given at 1 dose 30 minutes before the first feeding. The pill is dissolved in water to a thin suspension immediately before taking the drug.

At treatment of euthyroid goiter appoint 75-200 mcg / day.

For prevention of relapse after surgical treatment of euthyroid goiter - 75-200 mcg / day.

AT complex therapy of thyrotoxicosis - 50-100 mcg / day.

For suppressive treatment of thyroid cancer - 50-300 mcg / day.

At performing a thyroid suppression test use the following dosing regimen of the drug:

Hypothyroidism Eutirox® take, as a rule, throughout life. When thyrotoxicosis Eutirox® used in complex therapy with thyrostatics after reaching the euthyroid state. In all cases, the duration of drug treatment is determined individually.

Side effect

With proper use of Eutirox under the supervision of a physician, no side effects are observed.

In case of hypersensitivity to the drug, allergic reactions may occur.

Contraindications

- untreated thyrotoxicosis;

- untreated pituitary insufficiency;

- untreated adrenal insufficiency;

- acute myocardial infarction;

- acute myocarditis;

- acute pancarditis;

- increased individual sensitivity to the drug.

WITH caution the drug should be prescribed for ischemic heart disease (atherosclerosis, angina, myocardial infarction in history), arterial hypertension, arrhythmias, diabetes mellitus, with severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Use during pregnancy and lactation

During pregnancy and during breastfeeding, therapy with a drug prescribed for hypothyroidism should continue. When pregnancy requires an increase in the dose of the drug due to increased levels of thyroxin-binding globulin.The amount of thyroid hormone secreted in breast milk during lactation (even during treatment with high doses of the drug) is not enough to cause any disturbances in the child.

The use of the drug during pregnancy in combination with thyreostatics is contraindicated, because taking levothyroxine may require an increase in thyrostatic doses. Since thyreostatics, unlike levothyroxine, can penetrate the placenta, hypothyroidism can develop in the fetus.

During the period of breastfeeding the drug should be taken with caution, strictly in recommended doses under the supervision of a physician.

Use in children

At treatment of congenital hypothyroidism at children doses of the drug depend on age.

Use in elderly patients

When conducting hypothyroidism replacement therapy at patients under the age of 55 in the absence of cardiovascular diseases, Eutirox is prescribed in a daily dose of 1.6–1.8 mcg / kg of body weight; at patients older than 55 years or with concomitant cardiovascular diseases - 0.9 mcg / kg body weight.

With significant obesity, dose calculation should be done on "ideal weight".

At hypothyroidism replacement therapy initial dose for patients under the age of 55 years (in the absence of cardiovascular diseases) for women it is 75-100 mcg / day, for men - 100-150 mcg / day. For patients older than 55 years or with concomitant cardiovascular diseases the initial dose is 25 mcg / day; increase the dose should be 25 mcg with an interval of 2 months to normalize the level of TSH in the blood; when symptoms or deterioration of the cardiovascular system occur, correct the appropriate therapy.

special instructions

In hypothyroidism, caused by damage to the pituitary gland, it is necessary to find out whether there is at the same time adrenal insufficiency. In this case, glucocorticoid replacement therapy should be started before starting treatment of hypothyroidism with thyroid hormones in order to avoid the development of acute adrenal insufficiency.

Influence on ability to drive motor transport and control mechanisms

The drug does not affect the professional activities associated with driving vehicles and driving mechanisms.

Overdose

With an overdose of the drug are observed the symptomscharacteristic of thyrotoxicosis: palpitations, heart rhythm disturbances, heart pain, anxiety, tremor, sleep disturbances, excessive sweating, loss of appetite, weight loss, diarrhea.

Treatment: depending on the severity of symptoms, a decrease in the daily dose of the drug, a break in treatment for several days, the appointment of beta-blockers. After the disappearance of side effects, treatment should begin with caution with a lower dose.

Drug interaction

Levothyroxine enhances the effect of indirect anticoagulants, which may require lowering their dose.

The use of tricyclic antidepressants with levothyroxine can lead to an increased effect of antidepressants.

Thyroid hormones can increase the need for insulin and oral hypoglycemic drugs. More frequent monitoring of blood glucose levels is recommended during periods of initiation of treatment with levothyroxine, as well as when changing the dose of the drug.

Levothyroxine reduces the action of cardiac glycosides.

With simultaneous use of colestyramine, colestipol and aluminum hydroxide reduce the plasma concentration of levothyroxine due to inhibition of its absorption in the intestine. In this regard, levothyroxine must be applied for 4-5 hours before taking these drugs.

When used simultaneously with anabolic steroids, asparaginase, Tamoxifen , pharmacokinetic interaction is possible at the level of protein binding.

With simultaneous use with phenytoin, dicumarol, salicylates, clofibrate, Furosemide in high doses, the content of levothyroxine unbound with plasma proteins increases.

Taking estrogen-containing drugs increases the content of thyroxin-binding globulin, which may increase the need for levothyroxine in some patients.

Somatotropin when applied simultaneously with levothyroxine can accelerate the closure of the epiphyseal growth zones.

Consumption of phenobarbital, Carbamazepine and rifampicin may increase the clearance of levothyroxine and require an increase in dose.

Terms and conditions of storage

The drug should be stored in a dark, out of reach of children at a temperature not higher than 25 ° C.