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Symptomatic therapy of painful and inflammatory processes of various origins, including:

- rheumatoid arthritis and periarthritis;

- ankylosing spondylitis (ankylosing spondylitis);

- psoriatic arthritis;

- reactive arthritis (Reiter's syndrome);

- osteoarthritis of various localization;

- tendonitis, bursitis;

- myalgia;

- neuralgia;

- radiculitis;

- injuries of the musculoskeletal system (including sports), bruises of muscles and ligaments, sprains, ligaments and tendons of muscles.

Dosage and administration

For external use.

A small amount of cream (about 3-5 cm) with light rubbing movements is applied with a thin layer on the skin over the lesion. The cream is applied 2-3 times / day.

The duration of treatment without consulting a doctor should not exceed 14 days.

Adverse effects

Local reactions occur most frequently.

Determination of the frequency of adverse reactions: very often (≥1 / 10), often (≥1 / 100 and <1/10), infrequently (≥1 / 1000 and <1/100), rarely (≥1 / 10 000 and <1 / 1000), very rarely (<10 000).

Allergic reactions: very rarely - angioedema, anaphylaxis.

From the skin and skin appendages: infrequently - erythema, itching, burning, eczema, transient dermatitis of mild severity; rarely - urticaria, rash, photosensitization, bullous dermatitis, purpura, erythema multiforme, lichenoid dermatitis, skin necrosis,Stevens-Johnson syndrome; very rarely - a single case of severe contact dermatitis (against the background of poor hygiene and insolation), a single case of severe generalized photodermatitis, toxic epidermal necrolysis.

Respiratory: very rarely - asthma attacks (as an option for an allergic reaction).

Urogenital: very rarely - deterioration of renal function in patients with chronic renal failure.


- hypersensitivity to the drug;

- hypersensitivity to salicylates, tiaprofenic acid or other NSAIDs, to fenofibrate, blockers of UV rays, fragrances;

- violation of the integrity of the skin (eczema, oozing dermatitis, open or infected wound);

- indications of a history of bouts of bronchial asthma caused by taking NSAIDs and salicylates;

- photosensitivity reactions in history;

- exposure to sunlight, incl. indirect sunlight and UV radiation in a tanning bed during the entire period of treatment and another 2 weeks after stopping treatment;

- III trimester of pregnancy;

- children's age up to 15 years.

Carefully: abnormal liver and / or kidney function, erosive and ulcerative lesions of the gastrointestinal tract, blood diseases, bronchial asthma, chronic heart failure.

Use during pregnancy and lactation

The drug is contraindicated for use in the third trimester of pregnancy.

Application in the I and II trimesters is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use of the drug Ketonal ® during lactation (breastfeeding) is not recommended.

Application for violations of the liver

WITH caution It should appoint a drug in violation of the liver.

Application for violations of kidney function

WITH caution should be prescribed the drug in violation of the kidneys.

Use in children

Contraindications: children up to 12 years.

Special notes

Avoid getting the cream in the eyes, on the skin around the eyes, mucous membranes.

If any side effects occur, you should stop using the drug and consult a doctor.

If the patient forgot to apply the cream, it should be used at the time when the next dose should be applied, but not double it.

Ketonal® topical cream can be used in combination with other dosage forms of the drug Ketonal® (capsules, tablets, candles). The total daily dose, regardless of the dosage form, should not exceed 200 mg.

If skin reactions occur, incl. developed in combination with octocrylene-containing drugs, should immediately discontinue treatment.

To reduce the risk of photosensitivity, it is recommended to protect the cream-treated areas of the skin with clothing from the effects of UV rays throughout the entire treatment period and for another 2 weeks after discontinuing the use of the gel.

Do not use as occlusive dressings.

Hands should be washed thoroughly after each application.

Influence on ability to drive motor transport and control mechanisms

Data on the negative effects of the drug Ketonal® cream on the ability to drive vehicles and to other potentially dangerous activities that require concentration and speed of psychomotor reactions, no.


Symptoms: irritation, erythema, pruritus.

Treatment: should stop using the drug. The patient needs to see a doctor.

Drug interaction

Since the concentration of the drug in the blood plasma is extremely low, the manifestation of symptoms of interaction with other drugs (similar symptoms with systemic use) are possible only with frequent and prolonged use.

The simultaneous use of other topical forms (ointments, gels) containing Ketoprofen or other NSAIDs is not recommended.

Simultaneous administration of Acetylsalicylic acid reduces ketoprofen binding to plasma proteins.

Ketoprofen reduces the excretion of Methotrexate and increases its toxicity.

Interaction with other drugs and the impact on their elimination are not significant.

Patients taking coumarin-containing anticoagulants are advised to carry out treatment under the supervision of a physician.

Pharmacy sales terms

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.

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