ASCORBIC ACID AMPOULES 5% 2ML

Instruction

Release form

Injection solution

Composition

Active ingredient: Ascorbic acid 50 mg.

Excipients: sodium bicarbonate (sodium bicarbonate), sodium sulfite (sodium sulfite) 2 mg, water for injection, saturated with carbon dioxide to 1 ml.

Packaging

10 amp. on 2 ml.

Mechanism of action

Ascorbic acid has pronounced reducing properties, is involved in the regulation of carbohydrate metabolism, redox processes, blood clotting, normalization of capillary permeability, tissue regeneration, the synthesis of steroid hormones, collagen, procollagen.

Indications and usage

Ascorbic acid is used in preventive and therapeutic purposes in all clinical situations related to the need for additional administration of vitamin C. It is prescribed for the prevention and treatment of scurvy, for bleeding (nasal, pulmonary, uterine, caused by radiation sickness), hemorrhagic diathesis, for various intoxications and infectious diseases, nephropathy of pregnant women, Addison's disease, overdose of anticoagulants, bone fractures and sluggish wounds, various dystrophies, with increased mental strain enii and enhanced physical labor.

Contraindications

Hypersensitivity, with prolonged use in large doses (over 500 mg) - diabetes, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.

Carefully

Sideoblastic anemia, urolithiasis.

Use during pregnancy and lactation

During pregnancy and lactation Ascorbic acid is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child. The minimum daily need for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which a pregnant woman is taking, and then the development of a "withdrawal" syndrome is possible in a newborn. The minimum daily need during lactation is 80 mg. A mother's diet that contains an adequate amount of ascorbic acid is sufficient to prevent its deficiency in an infant. Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily need for ascorbic acid by the nursing mother).

Dosage and administration

Ascorbic acid is prescribed by a doctor. Ascorbic acid is prescribed intramuscularly or intravenously. For prophylactic purposes, adults are prescribed at 0.05 g-0.1 g per day; during pregnancyin the postpartum period and in the case of a low content of vitamin C in the milk of lactating women, 0.3 g per day is prescribed for 10-15 days, then prophylactically at 0.1 g per day during the entire lactation period. Children are prescribed prophylactically by 0.025 g 2-3 times a day. Therapeutic doses for adults are when taken orally, 05-0.1 g 3-5 times a day; for children - 0.05-0.1 g 2-3 times a day. Therapeutic doses for adults with parenteral administration is 1-3 ml of a 5% solution (2-6 ml of a 2.5% solution) per day. Children are prescribed parenteral 1-2 ml of 5% solution (2-4 ml of 2.5% solution) per day.

The course of treatment depends on the nature and course of the disease.

Adverse reactions

From the side of the central nervous system: with rapid intravenous administration - dizziness, feeling tired, with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.

On the part of the urinary system: moderate pollakiuria (when using a dose of more than 600 mg / day), with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from Calcium oxalate), damage to the glomerular apparatus of the kidneys.

Cardiovascular: with long-term use of large doses - a decrease in capillary permeability (possibly worsening of tissue trophism, increased blood pressure, hypercoagulation, the development of microangiopathies).

Allergic reactions: Allergic reactions up to the development of anaphylactic shock.

Laboratory values: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glycosuria.

Local reactions: pain at the site of intramuscular injection.

Other: with long-term use of large doses (more than 1 g) - inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria), when administered intravenously - the threat of abortion (due to estrogen), erythrocyte hemolysis.

 Overdose

Symptoms: nephrolithiasis, insomnia, irritability, hypoglycemia.

Treatment: symptomatic, forced diuresis.

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenal glands and blood pressure. High doses of ascorbic acid increase the excretion of oxalate, contributing to the formation of kidney stones. In newborns whose mothers took high doses of ascorbic acid, and in adults who took high doses, a ricochet of scurvy could be observed. With long-term use of large doses, the function of the insular apparatus of the pancreas may be inhibited, therefore during treatment it must be regularly monitored. In patients with a high content of iron in the body, ascorbic acid should be used in minimal doses. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood and urine levels of glucose, bilirubin, activity of “liver” transaminases and lactate dehydrogenase).

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and psychomotor speed.

Drug Interactions

Pharmaceutically incompatible with aminophylline, bleomycin, Cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, Erythromycin, methicillin, nafcillin, benzylpenicillin, Warfarin.

Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g / day increases the bioavailability of ethinyl estradiol (including part of oral contraceptives). Reduces the effectiveness of Heparin and indirect anticoagulants.

With simultaneous use with Acetylsalicylic acid increases the excretion of urine ascorbic acid and decreases the excretion of acetylsalicylic acid.

Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows the kidneys excretion of acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration in the blood of oral contraceptives. Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

Quinoline drugs, calcium preparations, salicylates, glucocorticosteroids with long-term use deplete the reserves of ascorbic acid.

With the simultaneous use of ascorbic acid reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, Ascorbic acid may interfere with the interaction of disulfiram and ethanol. In high doses, increases the excretion of meksiletina kidneys. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Storage conditions

In the dark place at a temperature of no higher than 15 ° C